tau protein


Also found in: Medical, Encyclopedia, Wikipedia.
Related to tau protein: Alzheimer disease

tau protein

n.
Any of several proteins that act to stabilize neuronal microtubules in the axons of brain neurons and that form abnormal tangles in the brains of people with certain neurodegenerative disorders.

[From the use of the Greek letter tau to represent the initial t- of tubulin, which it induces to form microtubules.]
Mentioned in ?
References in periodicals archive ?
In step two, they add a dementia-specific biomarker, give a result, is likely called tau protein, and run further tests on those people who tested positive in step one.
By targeting specific pathological forms of Tau protein, immunization with anti-Tau vaccines has become an important strategy for the treatment of AD and other Tauopathies because it has the potential to prevent and reduce the development and spread of Tau pathology throughout the brain.
Neurofibrillary tangles composed of aggregated tau protein is one of the pathological features of Alzheimer's disease (AD).
Women appeared to have better connectivity between the regions where tau protein builds up - and this had implications for the brain, the study said.
Wherever tangles of the tau protein appear, brain tissue dies, triggering the confusion and memory loss that are hallmarks of Alzheimer's.
Lack of such a cleansing operation due to lack of sleep, allows the accumulation of A-beta plagues around brain neurons which lead to an abnormal concentration of toxic tau protein (known as tangles) inside neurons.
has inked a research collaboration with the LuMind IDSC Foundation (LuMind IDSC) involving use of Cerveau's investigational imaging agent (MK-6240) in a multicenter clinical trial aimed at assessing accumulation of misfolded tau protein in people with Down syndrome, the company said.
Page 17 Dr Rosa Sancho, head of research from Alzheimer's Research UK said: "Lonafarnib should be explored as a potential way to target the tau protein. But this early work in mice still has a long way to go before we'll know whether it could be a medicine that benefits people with dementia."
A research team of Seoul National University has developed a blood test-based Alzheimer's disease diagnosis technology by checking for abnormal deposition of tau protein in the brain, the science ministry said Monday.
PSP is a rare neurological condition that causes severe problems with walking, balance, speech, swallowing and vision as a result of the accumulation of aggregates of the tau protein in the brain.
Results: There are many amounts of data supporting the view that AD pathogenesis so far there mainly are A[sz] toxicity, tau protein, gene mutation, synaptic damages, intermediate neurons and network abnormalities, changes in mitochondrial function, chemokines, etc., Its nosogenesis may be involved in multiple theories and involved in multiple molecular signaling pathways, including A[sz], tau protein, and synaptic anomaly; mutual relationship between the mechanisms urge jointly neuronal degeneration.