Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam
against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes.
In a pilot study, piperacillin (87 mg/kg) in combination with tazobactam
(11 mg/kg) was administered intramuscularly (IM) to 2 birds, and blood samples were obtained at 0, 0.
Antimicrobial discs used for sensitivity testing by disc diffusion method were Imepenem 10mcg, piperacillin/ tazobactam
100/10 mcg, Ceftazidime 30mcg Cefotaxime 30mcg, Amikacin 30mcg, Gentamicin 10mcg, Levofloxacin 5mcg, Ceftroaxone 30 mcg, Cefoxitin 30mcg, Amoxycillin/ Clavulanic acid 20/10mcg.
cefixime, ceftazidime, co-trimoxazole, ciprofloxacin, gentamicin, amikacin, cefoperazone + sulbactam, piperacillin + tazobactam
, meropenem, polymyxin - B, and aztreonam were used.
They tested 12 of the most common types of antibiotics, finding that two combinations in particular - piperacillin and tazobactam
, and imipenem and cilastatin - led to a higher risk of a life-threatening inflammatory condition called graft-versus-host disease (GVHD).
Although bone marrow suppression with leucopenia is mentioned as an important side effect of piperacillin/ tazobactam
, isolated thrombocytopenia without affection of red cells and leucocytosis has been reported only in few cases.
Broad spectrum antibiotic, Ceftriaxone and Tazobactam
(Intacef Tazo (a)) @ 10mg/kg b.
coli to be the most common gram-negative organism among post- chemotherapy febrile neutropenic patients, with susceptibility to imipenem, amikacin and piperacillin/ tazobactam
, and resistance to quinolones and third- generation cephalosporins.
In recent days the use of two different antibiotics in combination has been explored as a successful therapeutic option [16-18], Sulbactam and tazobactam
are an irreversible inhibitors of p-lactamase and they are given in combination with p-lactam antibiotics to inhibit p-lactamase , Sulbactam and tazobactam
are considered having intrinsic activity against Acinetobacter spp, and can be explored as a therapeutic option in combination with the drug of choice, which are being limited day by day, Sulbactam has been used in combination with ampicillin and cefoperazone for the treatment of Acinetobactor spp.
To prevent future confusion, the FDA has revised the labeling to show the sum of the two active ingredients, ceftolozane and tazobactam
(CAZ-TZP) ceftazidime-meropenem (CAZ-MEM) ceftazidime-ciprofloxacin (CAZ-CIP) and ceftazidime-amikacin (CAZ-AK) was evaluated by broth microdilution checkerboard technique (Verma 2007).
90] Amikacin [less than or 16 equal to] 8 Gentamicin >8 >8 Tobramycin >8 >8 Amoxicillin/ 16/8 >16/8 clavulanate Piperacillin/ [less than or >64 tazobactam
equal to] 8 Cefoxitin [less than or 16 equal to] 8 Cefotaxime >32 >32 Ceftazidime 16 >16 Cefepime >16 >16 Ciprofloxacin [less than or >2 equal to] 0.