In 2018, LinearRx and Takis/Evvivaxs collaboration showed immunogenicity in mice that were vaccinated with linear DNA against the human protein telomerase
that is over-expressed in more than 85% of all cancers.
Results: We identified a potentially damaging rare variant-a heterozygous mutation c.2146G>A in exon 6 of the gene encoding for telomerase
reverse transcriptase (TERT), which results in an amino acid substitution (p.Ala716Thr).
It has been hypothesised that telomere length and telomerase
activity may get reduced in hypertensive patients.
First, we need to focus on nutrients that increase telomerase
One of the promising targets in cancer therapy is the enzyme telomerase
. Normally, telomerase
prevents telomeres from shortening in germ and stem cells, which helps with development.
Decoding the architecture of the enzyme, called telomerase
, could lead to drugs that slow or block the ageing process, along with new treatments for cancer, they reported in the journal Nature.
Researchers at UC Berkeley have now mapped out the structure of telomerase
- an enzyme known to play a key role in aging and cancer - in more detail than ever before, and the breakthrough could inform a new generation of highly-targeted drugs.
TEMPE, Ariz., February 27, 2018 -- A new study performed here has uncovered a crucial step in the telomerase
enzyme catalytic cycle that determines the ability of the human telomerase
enzyme to synthesize DNA "repeats" (specific DNA segments of six nucleotides) onto chromosome ends, and so afford immortality in cells.
In proliferative cells, the length and integrity of telomeres are maintained by the action of a specialized reverse transcriptase, telomerase
In contrast, in most cancer cells, levels of the enzyme telomerase
, which lengthens telomeres, are elevated, allowing them to divide indefinitely.
In healthy stem cell reproduction, the enzyme telomerase
prevents the shortening of linear DNA ends (known as telomeres) with each replication.
Scientists from the US, Argentina, Israel, India, and Europe discuss electron cryptomography and its application to bacterial chemoreceptor arrays, designing symmetric protein nanomaterials, weighted ensemble simulation, eukaryotic transcription initiation machinery, biophysical models of protein evolution, rate constants and mechanisms of protein-ligand binding, the integration of bacterial small RNAs in regulatory networks, recognition of client proteins by the proteasome, chemokine receptor structures and function, progress in human Tetrahymena telomerase
structure determination, the theory and modeling of RNA structure and interactions with metal ions and small molecules, and reconstructing ancient proteins to understand the causes of structure and function.