Various animal-based test systems established for screening a potential teratogenic
activity are conducted on pregnant laboratory animals, usually mammals such as mice, rats, rabbits and nonhuman primates.
Congenital lymphocytic choriomeningitis virus: an unrecognized teratogenic
Dr Ito told BBC News: "Although the mechanism for the teratogenic
effect was made clear, the mechanism for its therapeutic effects remains unknown.
Each entry describes the following: synonyms, brand names, and street names; pharmacologic classifications; availability and use patterns; available dosage forms and routes of administration; the mechanisms of action related to the drug; current approved indications for medical use; reasons for personal use; basic toxicology (including adverse drug reactions); teratogenic
and fetotoxic potential; affects of maternal use on lactation and breast-fed infants; abuse potential; withdrawal symptoms; and overdosage.
Valproate appears to be the mood stabilizer associated with the greatest teratogenic
Certain agents are teratogenic
but more subtle effects at lower doses may occur although they are less readily detectable.
An apparent teratogenic
effect was associated with both ionic liquids, with only the offspring of treated mice exhibiting certain uncommon morphological defects, such as craniorachischisis, ectopia cordis, and ablepharia.
Immature fetal cells are much more vulnerable to the harmful effects of ionising radiation, (1,2) which may include early termination of pregnancy, teratogenic
effects and a small increase in the risk of childhood cancers.
Cytotoxic drugs are drugs that have a deleterious effects upon cells and many have been found to be mutagenic, teratogenic
The first major step is the elimination of all substances "teratogenic
, mutagenic, carcinogenic, or otherwise harmful in direct and obvious ways to human and ecological health." The second step is for designers to abandon the cradle-to-grave mentality and think about the life of the product and its packaging after it is bought.
However, another possible primary cause for such lesions is exposure to teratogenic
toxins, and this alone should warrant ongoing monitoring of breeding populations of little penguins and other species of high conservation status, especially those close to potentially contaminated major industrial areas such as Cockburn Sound near Penguin Island.
As CellCept has been shown to have teratogenic
effects in animals at subclinical doses on a body surface area basis, it may cause fetal harm when administered to a pregnant woman.