Tetraphase Pharmaceuticals, Inc., is a biopharmaceutical company using its proprietary chemistry technology to create novel tetracyclines
for serious and life-threatening conditions, including infections caused by many of the multidrug-resistant bacteria highlighted as urgent public health threats by the World Health Organization and the Centers for Disease Control and Prevention.
are the widely used therapeutic agents in human, veterinary medicines and also used in agriculture as growth promoter.
"We have known for 30-40 years that if you treat patients with tetracyclines
, the Staphylococcus epidermidis that we all have on our skin develop tetracycline
resistance," he said.
Light accelerates the degradation of tetracyclines
, including demeclocycline, when moisture and oxygen are present (20-24).
: drugs with huge therapeutic potential," Mini-Reviews in Medicinal Chemistry, vol.
A common drug that causes such photo sensitivity is an antibiotic belonging the family of tetracyclines
, the most modern of which, doxycycline, is taken twice a day for various infections.
Mass spectral characterization of tetracyclines
by electrospray ionization, H/D exchange, and multiple stage mass spectrometry.
Several antimicrobial drugs, including [beta]-lactams and tetracyclines
, effectively treat scarlet fever, and macrolides and lincosamides can be used in patients with penicillin ([beta]-lactam) allergy (4,5).
Among these compounds, the fluoroquinolones, [beta]-lactams, sulfonamides, and tetracyclines
are included .
Among antibiotics, tetracyclines
are the most commonly used and detected in the environment.
are broad-spectrum polypeptide antibiotic produced by the Streptomyces genus of Actinobacteria, indicated for use against many bacterial infections.