AG10 is an investigational, orally-administered small molecule designed to potently stabilize tetrameric
transthyretin, or TTR, thereby halting at its outset the series of molecular events that give rise to amyloidosis, or ATTR.
The team showed that the p.R336C mutation had a more profound effect not only on the amount of CBS enzyme made by the cells, but also the structural stability and activity, where the proper assembly and formation of a functional tetrameric
form of CBS was missing or degraded.
Lactate Dehydrogenase (LDH) is a tetrameric
molecule used to detect cell damage or cell death.
N-Methyl-D-aspartate receptors (NMDA) receptors are tetrameric
structures (8), consist of Grin1, Grin2 (A-D) and Grin3 (A-B) subunits (9), and mediates postsynaptic [Ca.sup.2+] influx in dendritic spines (3).
(23,24) Hemoglobin-based oxygen carrier substitutes, such as cross-linked tetrameric
hemoglobin and conjugated tetrameric
hemoglobin, may be beneficial as oxygen carriers and for their potential to reduce free HgbS, an oxidizer and proinflammatory agent.
Eidos' lead product candidate, AG10, is designed to target ATTR at its source by stabilizing tetrameric
TTR in the blood.
D) Mapping of antibody target sequences onto the tetrameric
P40 nucleoprotein 3D-structure (PDB:1N93).
Thus, a tetrameric
quaternary structure makes it very easy to recognize Dengue virus epitopes with serotype specificity (Bielifeldt-Ohmann, et al., 2001).
The [beta] Cas form oligomers from dimeric fundamental units and most commonly exist as tetramers with the tetrameric
interface perpendicular to that of the individual dimers.
Venkatachalam, "Structural and electrical studies on tetrameric
cobalt phthalocyanine and polyaniline composites," Materials Science and Engineering: B Advanced Functional Solid-State Materials, vol.
Binding of TGF-[beta] results in the formation of a tetrameric
receptor complex that propagates the signal by phosphorylation to the intracellular downstream effector proteins SMAD2 and SMAD3 (SMAD2/3).