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Related to thecoma: granulosa cell tumor


n. tecoma, tumor ovárico gen. benigno.
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The age range for thecoma fibroma group was 33-41 mean age 37+-1.5 years.
High scoring (=9) benign lesions were inflammatory adnexal masses, endometriomas, cystic teratomas, mucinous cystadenomas, and thecoma. Non-suspicious sonomorphology (score <9) was noted in 28 mass lesions- 26 were benign and 2 were malignant.
Ovarian thecoma with ascites and high serum levels of CA125.
The right ovary contained a huge (10 x 15 cm), multiloculated, mobile and well circumscribed mass with laparoscopic features similar to a benign ovarian mass especially an ovarian fibroma or thecoma (Figure 1).
TABLE When an adnexal mass is detected, possibilities are many EXTRAOVARIAN Ectopic Pedunculated fibroid Hydrosalpinx Tubo-ovarian abscess or diverticular abscess Inclusion cyst Fallopian tube cancer Appendicial tumor Pelvic kidney OVARIAN Simple ** follicular ** corpus luteum Complex ** endometrioma Metastalic ** breast ** gastrointestinal ** lymphoma Malignant, borderline, or benign ** epithelial --serous --mucinous --endometdoid --clear-cell --Brenner --mixed ** germ cell * --dysgerminoma --teratoma --endodermal sinus --choriocarcinoma --mixed ** sex-cord --granulosa-stromal (thecoma, fibroma) --androblastoma (Sertoli-Leydig) --gynandrobiastoma * Three percent of germ-ceil ovarian neoplasms are malignant; the majority are mature teratomas.
(e) All ovarian follicular cysts (abnormally large clear follicles), except one thecoma (MNU-TCDD), one hemorrhagic ovarian cyst (MNU-10x), and one atrophic ovary (MNU-10x).
However, stromal tumors themselves, including one of the best known ovarian tumors, the thecoma, have their own intriguing aspects, some of which have prompted recent contributions to the literature.
cases (242) % 1 Surface epithelial tumors 158 100 A Serous tumors 115 72.78 47.52 Benign 88 55.70 36.36 Borderline 2 1.27 0.83 Malignant 25 15.82 10.33 B Mucinous tumors 36 22.78 14.88 Benign 27 17.09 11.16 Borderline 4 2.53 1.65 Malignant 5 3.16 2.07 C Endometroid tumor 1 0.63 0.41 D Brenner tumor 6 3.80 2.48 2 Sex cord-stromal tumor 18 100 7.44 Granulosa cell tumor 10 55.56 4.13 Fibroma 3 16.67 1.24 Thecoma fibroma 4 22.22 1.65 Androblastoma 1 5.55 0.41 3 Germ cell tumors 58 100 23.96 Dysgerminoma 6 10.34 2.48 Yolk sac tumor 3 5.17 1.24 Mature cystic teratoma 43 74.14 17.77 Immature teratoma 2 3.45 0.82 Struma ovarii 3 5.17 1.24 Mixed germ cell tumor 1 1.72 0.41 4 Metastatic tumor 8 100 3.31
Benign solid tumors (Brenner, fibroma, thecoma, fibrothecoma) are all solid ovarian tumors that should be considered malignant with the exception of a few tumors like Brenner, fibroma, thecoma, and fibrothecoma.
(1-9) Roth and Ramzy (11,12) and others (4,13) have also described sclerosing stromal tumor or thecoma with signet ring cell transformation and ovarian epithelial or granulosa cell tumors with signet ring cell change in the nonneoplastic stroma.
(5) Because of the solid nature of mass, it is impossible to differentiate it from other solid ovarian neoplasms; for example, luteinized thecoma, granulosa cell tumor or leydig cell tumor based on imaging alone.
The benign tumors of ovaries comprised of three cases of mucinous cystadenoma, one case of serous cystadenoma and two cases of thecoma. One case of Granulosa cell tumor had endometrial hyperplasia due to estrogenic stimulus provided by the tumor.