Among these patients, 46 (59%) used at least 1 potentially dangerous medication (PD) and 37 (47.4%) at least one medication with a low therapeutic index
In these scenarios the possibility of rectal sparing with a single, mildly invasive procedure may be appealing to maximize the therapeutic index
"We believe its high potency, broad therapeutic index
, and favorable oral pharmacokinetics that allow a very rapid increase in exposure, followed by maintenance exposure with once-weekly dosing, highlight VT 1161's potential for onychomycosis," he said.
Lithium is notorious to have a narrow therapeutic index
, and, hence toxicity is a definitive risk, notably in hot climates in countries like this, where kids can be readily dehydrated.
However, committee members were much less certain of lesinurad's safety profile, which indicated a narrow therapeutic index
, and voted 7-6 in favor of adequate safety data to support approval, with 1 abstention.
Zalviso is a combination drug and device product which, using a patient controlled dispenser, delivers a sub-lingual formulation of sufentanil, an opioid with a high therapeutic index
Therefore, a factor to consider in evaluating a potential interaction with grapefruit is the drug's therapeutic index
and its risk of serious adverse effects.
Conclusion: The results of our study have shown that combination of gemcitabine and docetaxel in patients with advanced urothelial carcinoma of the urinary bladder, has a good therapeutic index
and stands as a reasonable first line option for such patients.
Medical researchers have a term, "therapeutic index
," which is a measure of how much therapeutic benefit we can achieve for a drug, per unit of adverse effect that the treatment gives to the patient.
44% of second M.B.B.S students and 46% of final M.B.B.S had good knowledge regarding therapeutic index
of a drug.
"Through in vivo toxicology studies, we have demonstrated that ADCs generated using Catalent's SMARTag platform have a better toxicity profile than a conventional ADC, while efficacy studies also point to an improved therapeutic index
. We look forward to partnering with Sanofi to support the development of their next generation of ADC products."
However, detailed studies will also be needed to ensure that agents considered for clinical development have acceptable general toxicity as well as preservation of an adequate therapeutic index
between cancer cells and normal host tissues."