Clinical studies have also been performed to analyze the impact of radiation treatment doses on the therapeutic ratio
. Zagars and Ballo found that patients benefited from external beam radiation therapy with treatment doses of 64-68 Gy when they were treated postoperatively for soft tissue sarcomas with clinical features predictive of increased local recurrence risk (i.e., positive margins; tumor location in the head, neck, and deep trunk; presentation with locally recurrent disease; patient age > 64 years; histopathologic subtype of malignant fibrous histiocytoma, neurogenic sarcoma, or ES; and tumor size > 10 cm).
Very Non-Toxic Getting More Toxic Approaching Poison Cannabis 1/20000 Psilocybin 1/1000 LSD 1/1000 Aspirin* 1/199 Nitrous Oxide 1/150 Prozac 1/100 Phenobarbital 1/50 DMT 1/50 Caffeine* 1/50 Ketamine 1/38 Rohypnol 1/30 Mescaline 1/24 Tobacco* 1/21 Methadone 1/20 Codeine 1/20 MDMA 1/16 Cocaine 1/15 Methamphetamine 1/10 Dextromethorphan 1/10 Alcohol 1/10 Isobutyl Nitrate 1/8 GHB 1/8 Heroin 1/6 DEA Drug Schedules Schedule IV or V (Prescribable, Low Danger) Schedule II or III (Prescribable, Dangerous) Therapeutic Ratio
is the ratio of: Effective Dose--Amount that works over Lethal Dose ?
Investigation of animal responses after intravenous (IV) administration of the mushroom was undertaken and relative data on established safe IV doses, lethal dose 50 (L[D.sub.50]), therapeutic index and therapeutic ratio
were discussed to authenticate its prospective beneficial effect.
For patients in advanced stages, however, a multidisciplinary approach is usually applied; for example, dissection of the primary tumor and selected regional lymph nodes is combined with salvage treatments such as radiotherapy and chemotherapy, which have a high therapeutic ratio
* Narrow therapeutic ratio
. The potential for complications increases in drugs with a narrow therapeutic ratio
, defined by the FDA as <2-fold difference between the median lethal dose and the median effective dose, or between the minimum toxic concentration and minimum effective concentration in the blood.
The combination is a good example of an excellent therapeutic ratio
: good activity and low toxicity," said study's senior investigator, Dr Edith Perez, director of Mayo Clinic's Breast Center in Jacksonville.
(13) To overcome the issue of inadequate dose, the radiation oncologist must attempt to increase the therapeutic ratio
to avoid normal tissue complications while increasing the dose to the tumor and, ultimately, increasing local control (Figure 6).
We conclude that interferon alpha-2b possesses greater therapeutic activity in vitro than ribavirin, with a potentially greater therapeutic ratio
Furthermore any new analog will have to have an acceptable therapeutic ratio
. The therapeutic ratio
of marijuana is not known because it has never caused an overdose death, but it is estimated on the basis of extrapolation from animal data to be 20,000 to 40,000.
of Re-188 HEDP in Skeletal Metastases Treatment.