thiamine pyrophosphate


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Noun1.thiamine pyrophosphate - a coenzyme important in respiration in the Krebs cycle
coenzyme - a small molecule (not a protein but sometimes a vitamin) essential for the activity of some enzymes
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Thiamine is a component of thiamine pyrophosphate, which participates in oxidative decarboxylation of pyruvic acid and [alpha]-ketoglutaric acid.
Thiamine, in the form of thiamine pyrophosphate (TPP), becomes an essential cofactor in glycolysis and mitochondrial oxidative decarboxylation of carbohydrates for energy formation [1, 3].
The enzyme PDH requires cofactor thiamine pyrophosphate. Thus, in case of thiamine deficiency, lactate cannot be metabolized to pyruvate and accumulates in large amounts resulting in severe lactic acidosis.