thiazolidinedione


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Related to thiazolidinedione: Alpha-glucosidase inhibitor, DPP-4 inhibitor

thi·a·zol·i·dine·di·one

 (thī′ə-zō′lĭ-dēn′dĭ-ōn′)
n.
Any of a class of drugs that decrease insulin resistance and are used to treat type 2 diabetes.
References in periodicals archive ?
It could also cause peripheral edema, and providers should be cautious when prescribing pregabalin with thiazolidinedione antidiabetic agents.
Moreover, increasing prevalence of diabetes has revved up consumption of medications such as sulfonylureas, insulin and thiazolidinedione's.
PIONEER 10 was a 57-week, randomised, open-label, active-controlled, parallel-group, multi-centre, single country trial with four treatment arms, comparing the safety, tolerability and efficacy of 3, 7 and 14 mg oral semaglutide with 0.75 mg dulaglutide (the approved dose by the Pharmaceutical and Medical Devices Agency (PMDA) in Japan) in Japanese people with type 2 diabetes inadequately controlled with one oral antidiabetic drug (sulfonylurea, glinide, thiazolidinedione, alpha-glucosidase inhibitor or sodium glucose cotransporter-2 inhibitor).
Three, a dipeptidyl peptidase-4 inhibitor, a sodium-glucose contransporter-2 inhibitor, or a thiazolidinedione may be added if insulin is unsuitable.
The article describes the Phase 1 study, in which the pharmacokinetic parameters of rosiglitazone, a thiazolidinedione agent commonly used for type 2 diabetes, were measured in the absence and presence of SCY-078 dosed to therapeutically relevant levels in healthy adult subjects.
Fifth, we were unable to draw any meaningful conclusions with regards to the impact of thiazolidinedione, insulin and 'other' oral anti-diabetic agents due to the small number of patients who used these agents during the study period.
Across two clinical trials, average HbAlc reductions of up to 1.4% and average weight loss of up to 3.1 pounds were achieved when Bydureon BCise was used as monotherapy or as an add-on to metformin, a sulfonylurea, a thiazolidinedione, or any combination of two of these oral antidiabetic medicines at 28 weeks.
A subgroup of patients who were using thiazolidinedione alone or in combination with other antidiabetic drugs were analysed.
Thiazolidinedione are PPARg agonists and by their action they improve glycaemic control in type 2 Diabetes mellitus (DM).
Madam, Pioglitazone is an antidiabetic of the thiazolidinedione (TZD) class.
For example, the polar thiazolidinedione nucleus of the TZDs and the polar carboxyl head group of the partial agonist ragaglitazar interact with the residues in this site.