Nonstandard abbreviations: MMPN, methylmercaptopurine nucleotide; TGN, thioguanine
Thiopurine drugs [6-mercaptopurine, (6-MP), thioguanine
(TG) and azathioprine] are widely used in the treatment of many diseases, such as acute leukaemia, different types of inflammatory and autoimmune diseases and in transplantation medicine.
The same study found that most plans covered the following drugs, with median copays ranging from $5-$40: lomustine, thioguanine
, bexarotene, erlotinib, exemestane, anastrozole, megestrol acetate, tamoxifen, chlorambucil, procarbazine, altretamine, and others.
KEY WORDS: azathioprine, thiopurine methyltransferase, thioguanine
Thiopurine derivatives, used as antineoplastic and immunosuppressive agents for the treatment of a number of autoimmune diseases, are metabolized to principle active metabolites, thioguanine
Consider the drugs thioguanine
and mereaptopurine, which are prescribed for acute leukemia, as well as to prevent rejection of organ transplants.
Although there are no data on hydroxyurea or thioguanine
among children, anecdotal reports indicate that they are very useful agents.
The patient was treated with high-dose all-transretinoic acid for 14 days, followed by a first induction chemotherapy regimen consisting of cytarabine, daunorubicine, and thioguanine
. Prophylactic treatment with fluconazole (400 mg/d) and trimethoprim-sulfamethoxazole (960 mg/d) was started because severe granulocytopenia.
Various immunomodulators including Azathioprine, Methotrexate, and thioguanine
analogues are frequently used for maintenance therapy 5].
The patients were initially treated on POG (Pediatric Oncology Group) 9421-DAT (daunomycin, cytosine arabinoside and Thioguanine
) based protocols, from 2000-2002 and then changed to Medical Research Council (MRC) AML 10 protocol.