The levels of total thiol
, non-protein thiol
, and protein thiol
were found significantly decreased in the spinal cord of 24-26-month-old rats relative to 3-4-month-old rats (7).
All patients had estimation of serum total thiol
by the method of Hu et al using DTNB and TRIS-EDTA buffer.
Blood samples were drawn from each patient to study a complete blood count, liver and renal function tests, electrolytes, and thiol/disulfide homeostasis parameters (thiol
, disulfide, native thiol
, disulfide/native thiol
, disulfide/total thiol
, native thiol/total thiol
Pedmark is a water-soluble thiol
compound that has the potential to prevent chemotherapy-induced hearing loss.
KEYWORDS: [beta]-thalassemia major, Disulfide, Ferritin, Oxidative stress, Thiol
One of these methods is to measure the thiol
Objective: To investigate novel oxidative stress marker thiol
disulphide homeostasis in patients with acute myocardial infarction.
Intracellular antioxidants are classified into two major groups as enzymatic (superoxide dismutase, catalase, glutathione peroxidase, thioredoxin, peroxiredoxin, and glutathion transferase) and non-enzymatic (lipoic acid, coenzim Q, vitamins C and E, thiol
, glutathione, and ferritin, transferin, ceruloplasmin and albumin as proteins) types (6-7).
Next, 1.5 mL of the blood sample was anticoagulated with EDTA for the preparation of erythrocyte hemolysate in order to determine the effects of DZN on the activities of antioxidant enzymes and 3.5 mL of the blood sample was transferred into plane tubes and centrifuged for 10 minutes at 1800Xg for serum separation in order to measure malondialdehyde (MDA), total thiol
molecules, and total antioxidant capacity (TAC) as biomarkers of oxidative stress in blood serum.
, total thiol
, disulphide levels and disulphide/native thiol
, disulphide/total thiol
, and native thiol/total thiol
ratios were compared between the patient and control group's sera.
One of the defense mechanism against OS in humans is the thiol
The aim of this prospective study was to evaluate the role of oxidative stress, using native thiol
thiol/disulfide (SH/SS) homeostasis as a novel indicator, in the etiology of BPPV.