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A phenothiazine drug, C21H26N2S2, that is used in the form of its hydrochloride to treat psychotic disorders.

[thio- + (pipe)rid(ine) + azine.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pharmacology) C21H26N2S2, an oral tranquillizer used to treat psychological disorders
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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Noun1.thioridazine - a tranquilizer (trade name Mellaril) used to treat schizophrenia and other psychotic disorders
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References in periodicals archive ?
Chlorpromazine (Thorazine), clozapine (Clozaril), methotrimeprazine (Nozinan), olanzapine (Zyprexa), perphenazine (Trilafon), pimozide (Orap), quetiapine (Seroquel), thioridazine (Mellaril), and trifluoperazine (Stelazine).
Antipsychotic Drugs: Clozapine, Olanzapine, Perphenazine, Quetiapine, Thioridazine, Trifluoperazine, Loxapine, Methotrimeprazine, Molindone, Pimozide
They found that those receiving clozapine, thioridazine, and haloperidol were 2 to 3 times more likely to develop seizures than those treated with risperidone; risks associated with the rest of the FGAs were similar to that of risperidone.
Unfortunately, both thioridazine and clozapine have serious side effects.
Previous work in our laboratory has demonstrated that three phenothiazine derivatives, chlorpromazine, chlorprothixene, and thioridazine, have bacteriostatic activity against Neisseria species.
Antipsychotics with a high severity of these effects include chlorpromazine, thioridazine, clozapine, olanzapine, and haloperidol [3, 8].
Comparing the potency over the inhibition of the K+ channels and the prolongation of the QT interval with the plasmatic therapeutic levels of the drugs, the difference between the inhibiting potency and the therapeutic dosage is greater in the case of quetiapine, olanzapine and risperidone, while thioridazine shows the lowest difference (2).
Atypical antipsychotics; risperidone, olanzapine, and a typical antipsychotic, thioridazine, led to acute dystonic reactions (ADRs) in our patients.
Animal research supports the beneficial effects of sodium bicarbonate in case of thioridazine toxicity [49].
* Extreme sensitivity to antipsychotic medications used to control behavioral symptoms in other types of dementia-such as haloperidol (Haldol) and thioridazine (Mellaril)--resulting in worsening of movement disorders in people with DLB, and possibly kidney failure or even death.
Of the commonly used antidepressants, Citalopram and Escitalopram have been found to prolong the QT interval.6 Beach et al.1 showed that Thioridazine, Ziprazidone and IV Haloperidol were the antipsychotics which had the greatest propensity for prolonging the QT interval and to be associated with Torsades de Pointes.