Chlorpromazine (Thorazine), clozapine (Clozaril), methotrimeprazine (Nozinan), olanzapine (Zyprexa), perphenazine (Trilafon), pimozide (Orap), quetiapine (Seroquel),
thioridazine (Mellaril), and trifluoperazine (Stelazine).
Antipsychotic Drugs: Clozapine, Olanzapine, Perphenazine, Quetiapine,
Thioridazine, Trifluoperazine, Loxapine, Methotrimeprazine, Molindone, Pimozide
They found that those receiving clozapine,
thioridazine, and haloperidol were 2 to 3 times more likely to develop seizures than those treated with risperidone; risks associated with the rest of the FGAs were similar to that of risperidone.
Unfortunately, both
thioridazine and clozapine have serious side effects.
Previous work in our laboratory has demonstrated that three phenothiazine derivatives, chlorpromazine, chlorprothixene, and
thioridazine, have bacteriostatic activity against Neisseria species.
Antipsychotics with a high severity of these effects include chlorpromazine,
thioridazine, clozapine, olanzapine, and haloperidol [3, 8].
Comparing the potency over the inhibition of the K+ channels and the prolongation of the QT interval with the plasmatic therapeutic levels of the drugs, the difference between the inhibiting potency and the therapeutic dosage is greater in the case of quetiapine, olanzapine and risperidone, while
thioridazine shows the lowest difference (2).
Atypical antipsychotics; risperidone, olanzapine, and a typical antipsychotic,
thioridazine, led to acute dystonic reactions (ADRs) in our patients.
Animal research supports the beneficial effects of sodium bicarbonate in case of
thioridazine toxicity [49].
* Extreme sensitivity to antipsychotic medications used to control behavioral symptoms in other types of dementia-such as haloperidol (Haldol) and
thioridazine (Mellaril)--resulting in worsening of movement disorders in people with DLB, and possibly kidney failure or even death.
Of the commonly used antidepressants, Citalopram and Escitalopram have been found to prolong the QT interval.6 Beach et al.1 showed that
Thioridazine, Ziprazidone and IV Haloperidol were the antipsychotics which had the greatest propensity for prolonging the QT interval and to be associated with Torsades de Pointes.
