thiotepa


Also found in: Thesaurus, Medical, Wikipedia.
Related to thiotepa: busulfan

thi·o·te·pa

 (thī′ō-tē′pə, -tĕp′ə)
n.
A crystalline compound, C6H12N3PS, a sulfur-containing analog of tepa, used to treat certain malignant tumors.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

thiotepa

(ˌθaɪəˈtiːpə)
n
(Pharmacology) a drug, C6H12N3PS, used in chemotherapy to destroy cancer or neoplastic cells
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.thiotepa - an antineoplastic drug used to treat certain malignancies
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
The study utilized a lentiviral vector containing the human beta-globin gene and a conditioning protocol with treosulfan and thiotepa. The data presented today and included in this release were analyzed as of April 2019.
Their results support that in NMIBC, intravesical BCG therapy for variant histology has better prognosis in terms of progression and cancer-specific survival than other intravesical treatments (mitomycin C and thiotepa) with no need for additional treatment.
Busulfan, melphalan, or alkylating agents such as thiotepa, especially in the autologous setting, are among the risk factors for the late onset SOS (49,50).
reported 17 patients with PTCLs using a fludarabine, cyclophosphamide, and thiotepa as RIC regimen.[28] Estimated 3-year cumulative PFS and OS rates were 64% and 81%, respectively, and the 2-year cumulative non-relapse mortality rate was only 6%.[28] Although this result is specially encouraging, the limited patients and heterogeneity of lymphomas make it very difficult to evaluate the role of the intensity in conditioning regimen.
Thiotepa was first used in 1961 for this purpose, and mitomycin C and doxorubicin became available in time (9).
This vigorous multi-modality regimen showed improved survival rate over conventional therapy.3 Ferreri et al., based their phase II trial on MATILDE regimen which included high dose methotrexate combined with CNS penetrating chemotherapeutic agents (cytarabine, idarubicin and thiotepa) followed by response tailored radiotherapy.
High-dose busulfan, melphalan and thiotepa followed by autologous peripheral blood stem cell (PBSC) rescue in patients with advanced stage III-IV ovarian cancer.
As a salvage, in analogy to acute lymphoid leukemia, intrathecal combinational chemotherapy with methotrexate, cytosine arabinoside, and dexamethasone (15 mg, 40 mg, and 4 mg, resp.) is often applied continuously until liquor clearance, usually in combination with high-dose chemotherapy, using drugs with known CNS penetration (methotrexate, cytosine arabinoside, idarubicin, and thiotepa), together with high-dose dexamethasone, similar to what we normally do in CNS lymphoma.
It has been reported that a GST inhibitor (ethacrynic acid, EA) combined with alkylating agents (Chl and thiotepa) for the treatment of tumor showed some success [91].