McMillin, "Simultaneous UPLC-MS/MS assay for the detection of the traditional antipsychotics haloperidol, fluphenazine, perphenazine, and thiothixene
in serum and plasma," Clinica Chimica Acta, vol.
Typical antipsychotics like haloperidol, thiothixene
, and flupentixol increase TST and Sleep Efficiency (SE) and reduce Sleep Latency (SL) and awakenings [5, 6].
Currently, she was taking thiothixene
20 mg three times daily (daughter had reduced it to two times daily to avoid running out) and benztropine 1mg daily.
The patient remained fever-free for the next few days and was started on Thiothixene
Figure 2: The pharmacological agents that were tested included the following: First-generation antipsychotics: Flupenthixol decanoate Haloperidol Thiothixene
Second-generation antipsychotics: Aripriprazole Olanzapine Ziprasidone Mood stabilisers: Carbamazepine Valproate semisodium Lamotrigine Topiramate Antidepressants: Amitriptyline Fluoxetine Fluvoxamine Phenelzine sulfate Mianserin Dietary supplementation: Omega-3 fatty acid However, these claims were made based on single study effects and therefore require replication.
Most (70%) were taking a drug with a moderate risk (risperidone, chlorpromazine, paliperidone, thiothixene
, or trifluoperazine).
Prescribed typical antipsychotics within the study period included chlorpromazine, clopenthixol, clothiapine, droperidol, flupentixol, fluphenazine, haloperidol, levomepromazine, loxapine, methotrimeprazine, perphenazine, pipotiazine, sulpiride, thioridazine, thiothixene
, and trifluoperazine.
(10,11) The drugs implicated are phenothiazines (especially chlorpromazine), thiothixene
, fluphenazine, fluspirilene, loxapine and levomepromazine.
Antipsychotic Medications, Generic and Brand Names and Typical Tablet Dosage Generic Name Brand Name Tablet dosage range Atypical Risperidone Risperdal 1-3 mg Olanzapine Zyprexa 2.5-10 mg Clozapine Clozaril 25-100 mg Quetiapine Seroquel 25-200 mg Ziprasidone Geodon 20-60 mg Aripiprazole Abilify 5-15 mg High Potency Haloperidol Haldol 0.5-20 mg Typical Pimozide Orap 2 mg Fluphenazine Prolixin 2.5-10 mg Medium Potency Trifluoperazine Stelazine 1-10 mg Typical Perphenazine Trilafon 2-16 mg Thiothixene
Navane 2-20 mg Loxapine Loxitane 5-50 mg Low Potency Molindone Moban 5-100 mg Typical Mesoridazine Serentil 10-100 mg Thioridazine Mellaril 10-200 mg Chlorpromazine Thorazine 10-200 mg Adapted from Wilens (1999) and Li, Pearrow, & Jimerson (2010).
In 1970 antipsychotics (haloperidol, levomepromazine, thiothixene
) were recommended in Sweden as the first-line treatment of anxiety in organic brain syndromes, psychoasthenia and substance abuse.