The patient remained fever-free for the next few days and was started on Thiothixene
Figure 2: The pharmacological agents that were tested included the following: First-generation antipsychotics: Flupenthixol decanoate Haloperidol Thiothixene
Second-generation antipsychotics: Aripriprazole Olanzapine Ziprasidone Mood stabilisers: Carbamazepine Valproate semisodium Lamotrigine Topiramate Antidepressants: Amitriptyline Fluoxetine Fluvoxamine Phenelzine sulfate Mianserin Dietary supplementation: Omega-3 fatty acid
Most (70%) were taking a drug with a moderate risk (risperidone, chlorpromazine, paliperidone, thiothixene
, or trifluoperazine).
Prescribed typical antipsychotics within the study period included chlorpromazine, clopenthixol, clothiapine, droperidol, flupentixol, fluphenazine, haloperidol, levomepromazine, loxapine, methotrimeprazine, perphenazine, pipotiazine, sulpiride, thioridazine, thiothixene
, and trifluoperazine.
Lower dosage or avoid use Perphenazine Phenothiazines are contraindicated with significant hepatic impairment Thiothixene
Specific guidelines not available.
10,11) The drugs implicated are phenothiazines (especially chlorpromazine), thiothixene
, fluphenazine, fluspirilene, loxapine and levomepromazine.
5-10 mg Medium Potency Trifluoperazine Stelazine 1-10 mg Typical Perphenazine Trilafon 2-16 mg Thiothixene
Navane 2-20 mg Loxapine Loxitane 5-50 mg Low Potency Molindone Moban 5-100 mg Typical Mesoridazine Serentil 10-100 mg Thioridazine Mellaril 10-200 mg Chlorpromazine Thorazine 10-200 mg Adapted from Wilens (1999) and Li, Pearrow, & Jimerson (2010).
Some of the drugs given this label include prochlorperazine, haloperidol, loxapine, thioridazine, molindone, thiothixene
, pimozide, fluphenazine, and perphenazine.
There are several decades' worth of data from large studies supporting the reproductive safety of the typical antipsychotics such as haloperidol or thiothixene
, but the reproductive safety data for the atypical antipsychotics are extremely sparse.