thiouracil


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thi·o·u·ra·cil

 (thī′ō-yo͝or′ə-sĭl′)
n.
A white crystalline compound, C4H4N2OS, that interferes with the synthesis of thyroxine, used to reduce the action of the thyroid gland, especially in the treatment of hyperthyroidism.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

thiouracil

(ˌθaɪəʊˈjʊərəsɪl)
n
(Pharmacology) a white crystalline water-insoluble substance with an intensely bitter taste, used in medicine to treat hyperthyroidism; 2-thio-4-oxypyrimidine. Formula: C4H4N2OS
[from thio- + uracil (uro-1 + ac(etic) + -il -ile)]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.thiouracil - depresses the function of the thyroid gland
organic compound - any compound of carbon and another element or a radical
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
[31] 13 Pleural effusion Pleural Authors Treatment Outcome Battle and Stasney [5] Supportive Death, 2 months Rubinstein [6] Thiouracil Death, 2 months Franklin et al.
Chen, "Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors," European Journal of Medicinal Chemistry, vol.
Caption: FIGURE 13: Structures of 6-thioguanine (1); 7-deazaguanine (2); 8-aza-7-deaza-isoguanine (3); pyrene (4) and perylene (5) tethered to C8 of guanine; 6-methyl-isoxanthopterin (6); zebularine or 2-pyrimidinone-riboside (7); and 4- thiouracil (8).
PTU is a thiouracil derivative that is considered as one of the most commonly used antithyroid drugs in the hyperthyroidism management [28].
Patients with dysthyroidism were diagnosed as hypothyroid or hyperthyroid according to their thyroid profile and treated accordingly with L-thyroxine or propyl thiouracil. Thyroid function test was repeated every 6 weeks, and drug doses were adjusted accordingly.
Rarely, neutropenia may occur as a result of idiosyncratic supression of myeloid production with antibiotics, anti-diabetics, antihistaminics and antihypertensive drugs, destruction of neutrophils related with differences in drug metabolism (phenothiazine, thiouracil) and leukocyte destruction due to antibodies developing against the leukocyte-drug complex (phenylbutasone, chlorpropamide) (3, 4, 7, 8).
Group E was fed diet 5 (20% canola oil and CCT supplement (Cholesterol, cholic acid, thiouracil comparison of means for lipid profilesofall groups was carried out by analysis of variation (ANOVA) for parametric data and Kruskal Wallis test for non-parametric results.
Thiouracil refers both to a specific molecule consisting of a sulfated uracil and a family of molecules based upon the structure.
Outcome of Structure Activity Relationship (SAR) study depicted the thiouracil nucleus as essential for the antimicrobial activity and substitution at position 5 of 2-thiouracil gave active compounds as antibacterial, antiviral, and antineoplastic; hence, the substituents group like thiourea in compound (86), pyridine moiety in compound (87), benzene nucleus with N[O.sup.2] group in compound (88), and thiazole ring in compound (89) were found to show potent in vitro antimicrobial activity [124].