thromboxane


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throm·box·ane

 (thrŏm-bŏk′sān)
n.
Any of several compounds, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels.

thromboxane

(θrɒmˈbɒkseɪn)
n
a substance formed from prostaglandin precursors in platelets that promotes the constriction of blood vessels and aids blood clotting

throm•box•ane

(θrɒmˈbɒk seɪn)

n.
a compound, C20H32O5, formed in blood platelets, that constricts blood vessels and promotes clotting.
[1975; thromb (us) + ox- + -ane]
References in periodicals archive ?
This risk reduction is due to the antiplatelet effects of aspirin: inhibiting production of thromboxane decreases activation and clumping of platelets.
Its antiplatelet mechanism is different from the action of aspirin on prostaglandin E2 and thromboxane A2.
Aspirin inhibits platelet cyclooxygenase and thromboxane A2 and has been the most widely used antiplatelet agent.
Effect of endogenously produced leukotrienes and thromboxane on renal vascular resistance in rabbit hydronephrosis.
Currently, the rationale for using aspirin to prevent preeclampsia lies with its ability to inhibit platelet production of thromboxane and block NF-kB, a protein complex that plays a role in systemic and /or decidual inflammation.
Some authors have suggested the ventricular dysfunction is secondary to either pulmonary hypertension caused by serotonin and thromboxane or systemic hypotension caused by vagal stimulation [1,11].
(12,13) The specific inhibition of COX-2 alters the balance between platelet-derived thromboxane [A.sub.2] ([TXA.sub.2]) and endothelium-derived [PGI.sub.2], leading to increases in the risk of thrombosis due to altered vascular tone.
Patients were considered nonresponsive (not protected) if their serum thromboxane level remained high enough to raise the risk of blood clotting within 72 hours after taking three doses of aspirin.
Inhibitory effects of resveratrol on platelet activation induced by thromboxane a(2) receptor agonist in human platelets.
Thromboxane [A.sub.2] ([TXA.sub.2]) is mainly derived from platelets and vascular endothelial cells.
Thromboxane [A.sub.2] (TX[A.sub.2]) and prostacyclin (PG[I.sub.2]) are downstream products of COX-2.
Equal amounts of protein were assayed by [PGE.sub.2] enzyme-linked immunosorbent assay (ELISA) (Cayman Chemical) and thromboxane [B.sub.2] ([TXB.sub.2]) ELISA kit (Enzo Life Science, NY, USA).