1] Nonstandard abbreviations: ATD, autoimmune thyroid diseases; TPO, thyroid peroxidase; Tg, thyroglobulin
antibodies were present in only 25% of the total population.
Immunohistochemical studies were carried out on the cell block and core biopsy sections using antibodies TTF-1 (1:200; Leica), thyroglobulin
(1:1000; Dako), ER (1:50; Dako), PR (premade; Leica), GATA3 (1:200; Cell Marque), GCDFP-15 (1:500; Leica), CD56 (Premade; Leica), synaptophysin (1:200; Dako), chromogranin (1:200; Cell Marque), pAx8 (1:100; Cell Marque), villin (1:100; Leica), CK 7 (1:400; Dako) and CK20 (1:200; Novocastra).
The IHC characterization of the thyroid cells was performed with antibodies against thyroglobulin
(specific for thyroid follicular cells) and calcitonin (specific for thyroid C-cells [or parafollicular cells]) (RAMOS-VARA et al.
Apart from the aforementioned points, the discrepancy between the actual thyroglobulin
(Tg) level and the posttreatment imaging findings has also been mentioned as a weighing factor for high recurrence risk in the ATA guidelines, based on its predictive value for both ablation success and prognosis.
A total body scan 8 weeks post laminectomy (when 24 hour urine iodine < 100 microgram/litre, and TSH was 38 mIU/ml after thyroid hormone withdrawal) was negative, the thyroglobulin
level was 5 ng/ml and negative antithyroglobulin antibody (at that period of time, positron emission tomography (PET) scan was not an available option).
Diagnostic value of serum thyroglobulin
measurements in the follow-up of differentiated thyroid carcinoma, a structured meta-analysis.
synthesis is known to increase with the stimulation of TSH in thyroid cells.
5) It exhibited organoid and trabecular pattern with hyalinized stroma, positive immunostaining for calcitonin and negative staining for thyroglobulin
1) In order to establish iodine status in an individual with thyroid disease or suspected thyroid disease, I suggest using a 24 hour iodine urine test and a serum thyroglobulin
To the Editor: I read the recent article (1) on the relationship between thyroglobulin
and recurrence of thyroid cancer with great interest.
When thyroid cancer metastasizes, lymph nodes in the neck may be affected, but these lymph-node tumors can be tiny and may not be detected by ultrasounds done before surgery to remove the diseased thyroid--or even during the procedure itself, hi an international academic study published in the December issue of the journal Surgery, UCLA researchers and colleagues demonstrated that routine removal of neck lymph nodes during initial thyroid surgery for papillary cancer may lead to lower disease recurrence rates and lower levels of thyroglobulin
, a thyroid tumor marker that can be an indicator of disease when elevated.