ticlopidine


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Related to ticlopidine: dipyridamole, ticlopidine hydrochloride

ti·clo·pi·dine

 (tī-klō′pə-dēn′)
n.
A drug that blocks platelet aggregation, C14H14ClNS, used in its hydrochloride form to prevent stroke and to treat intermittent claudication.

[t(h)i(o)- + c(h)lo(ro)- + p(yr)idine.]
References in periodicals archive ?
Comparison of antiplatelet effects of aspirin, ticlopidine, or their combination after stent implantation.
There are three aggregation inhibitors: ciostazol (Pletal), rated C; clopidogrel (Plavix), rated B; and ticlopidine (Ticlid), rated B.
the supplier entered the market in the United States earlier this year by introducing ticlopidine hydrochloride, which is said to help reduce the risk of stroke and is comparable to Roche Laboratories' Ticlid.
After the procedure, she was started on aspirin 300mg daily and ticlopidine 250mg twice daily to decrease thrombus formation.
The results of those studies "have not clearly established that [clopidogrel] is superior to or even equivalent to" aspirin, aspirin plus dipyridamole, and ticlopidine (Ticlid), said last year's treatment recommendations from the American Heart Association and American Stroke Association.
Objective: The purpose of this study was to compare the effects of ticlopidine and clopidogrel on the development of neointimal hyperplasia after experimental arterial injury.
Although TMA with calcineurin inhibitor (CNI)-based immunosuppression has been known to exist since the late 1980s, newer therapeutic regimens in transplantation also have been reported to cause this vascular and glomerular lesion, such as the anti-CD3 monoclonal antibody muronomab-CD3 (OKT3) (19) and the addition of the antiaggregating agents clopidogrel (20-22) and ticlopidine (22,23) to a CNI-based regimen.
Ticlopidine is a thienopyridine derivative that irreversibly inhibits platelet aggregation by blocking the adenosine diphosphate (ADP) receptor, and it requires metabolism in the liver for this activity to take place.
Patients were treated with acetylsalicylic acid (100 mg) and Ticlopidine (250 mg) or Clopidogrel (75 mg) daily for 1 month after PTCA.
Current guidelines for TIA and ischemic stroke prevention recommend aspirin as the first choice but refer to the three alternatives now available: Aggrenox, ticlopidine, and clopidogrel, said Dr.