tissue plasminogen activator

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Related to tissue plasminogen activator: streptokinase

tissue plasminogen activator

n. Abbr. tPA or TPA
1. A clot-dissolving enzyme that is produced naturally by cells in the walls of blood vessels and catalyzes the conversion of plasminogen to plasmin.
2. A preparation of this enzyme that is produced by genetic engineering and is used as a drug to dissolve blood clots in the immediate treatment of certain cases of stroke and heart attack.


or tPA,

tissue plasminogen activator: an anticlotting enzyme of the blood, produced in quantity by genetic engineering for use in dissolving blood clots.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tissue plasminogen activator - a thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clottissue plasminogen activator - a thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clot; used in treating acute myocardial infarction
clot buster, thrombolytic, thrombolytic agent - a kind of pharmaceutical that can break up clots blocking the flow of blood to the heart muscle

tissue plasminogen activator (tPA)

n activador m tisular del plasminógeno, activador del plasminógeno tisular
References in periodicals archive ?
Though limited by a smaller number of postimplementation cases and lack of 3-month poststroke functional outcome data, the findings suggest that 24/7 in-hospital availability of a neurologist improves door to intravenous tissue plasminogen activator treatment times and in-hospital stroke mortality, Dr.
3) Alteplase 20 mg (Recombinant Tissue Plasminogen Activator (TNK-t-PA) 20 mg )
Recombinant tissue plasminogen activator for acute ischaemic stroke an updated systematic review and meta-analysis.
Alteplase, or tissue plasminogen activator, is ideally given in the first three hours upon onset of acute stroke,' Tayag said at a press briefing, stressing that only patients who have an ischemic type of stroke, or those with blocked blood vessels in the brain, will benefit from the medicine since alteplase breaks down unwanted blood clots.
Keywords: acute ischemic stroke (AIS), intracranial hemorrhage (ICH), tissue plasminogen activator (t-PA)
After failure of streptokinase thrombolysis with IV recombinant tissue plasminogen activator (TPA)was studied.
The company will be enrolling around 60 patients in the trial from around 15 sites within and outside the United States with Rutherford Category IIa and IIb acute lower limb ischemia receiving catheter-directed recombinant tissue plasminogen activator and compare a high and low dose of MST-188 against recombinant tissue plasminogen activator alone.
The proportion of patients discharged home increased from 38% to 43%, rates of symptomatic intracranial hemorrhage decreased from 6% to 5%, and complications from tissue plasminogen activator (TPA) treatment decreased from 7% to 6%, said Dr.
Recombinant tissue plasminogen activator (rtPA), which is commonly used for the treatment of myocardial infarction and stroke in adults, has also been used to treat cardiac thrombi in patients with congenital heart disease and right-to-left shunting (2), (3), (4).
It is not very clear, except in hypertensive emergencies, aortic dissection and after tissue plasminogen activator how to best manage blood pressure after stroke.
After incubating the blot with blocking buffer (5% non-fat dry milk in TBS) overnight at 4[degrees]C, tissue plasminogen activator antibody (anti t-PA, 1:250 to 1:1000 in blocking buffer) was added and incubated for 1 hr at room temperature.
Plasmin degradation of the alpha chain of fibrinogen/fibrin: improved activation constant and activity determination in assays for tissue plasminogen activator