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Noun1.tolazamide - a drug (trade name Tolinase) used in treating stable adult-onset diabetes mellitus
sulfonylurea - antidiabetic consisting of any of several drugs that reduce the level of glucose in the blood; used to treat diabetes mellitus
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Six drugs are included in this subclass: chlorpropamide, glimepiride (Amaryl), glipizide (Glucotrol), glyburide, tolazamide (Tolinase), and tolbutamide.
The following chemicals tested in ToxCast[TM] were used as signpost chemicals: troglitazone, tributyltin chemicals, nicotine, haloperidol and chlorpromazine, tolazamide, amitraz, dexamethasone, nicotinic acid (niacin), and chlorinated persistent organic pollutants (POPs).
The first generation of sulfonylureas are tolbutamide, tolazamide, and actohexamide and the second generation of sulfonylureas are glyburide, glipizide, gliclazide, glimepiride, and others.
It has been indicated that some specific hypoglycaemic medications such as glyburide, phenformin and tolazamide decrease endogenous content of CoQ10.
Modifications of antidiabetic drugs in patients with type 2 diabetes mellitus (adapted from the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines) Class Drug Dosing recommendation stages 3 and 4 CKD or kidney transplant First-generation Acetohexamide, Avoid sulfonylureas tolazamide, tolbutamide Chlorpropamide Avoid when GFR < 50 mL/min/ 1.
The first generation sulfonylureas (tolbutamide, tolazamide and chlorpropamide) are rarely used now.
The second-generation agents, glimepiride (Amaryl[R]), glipizide (Glucotrol[R] and Glucotrol XL[R]), and glyburide (Diabeta[R], Micronase[R], and Glynase[R]), have shorter half-lives and shorter onset of action than the first generation sulfonylureas such as chlorpropamide, (Diabinese[R]), tolazamide (Tolinase[R]), and tolbutamide (Orinase[R]).
The first-generation sulfonylureas currently available are chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide (Orinase).
xx Actos, Amaryl, Avandamet, Avandia, chlorpropamide, Diabeta, Diabinese, Fortamet, Glipizide, Glipizide ER, Glipizide XL,Glucophage, Glucophage XR, Glucotrol, Glucotrol XL, Glucovance, glyburide, glyburide micronized, glyburide-metformin, Glynase, Glyset, Humalog, Humalog Mix 75/25, Humulin 50/50, Humulin 70/30, Humulin L, Humulin N, Humulin R, Humulin U, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin NPH, Lantus, Metaglip, metformin, metformin ER, Micronase, Novolin 70/30, Novolin L, Novolin N, Novolin R, Novolog, Novolog Mix 70/30, Prandin, Precose, Riomet, Starlix, tolazamide, tolbutamide, Tolinase, Velosulin Human BR ED = Erectile dysfunction; ICD-9-CM = International Classification of Diseases, 9th Edition, Clinical Modification; HCTZ = hydrochlorothiazide.