tolbutamide


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to tolbutamide: acarbose, metformin

tol·bu·ta·mide

 (tŏl-byo͞o′tə-mīd′)
n.
A sulfonylurea drug, C12H18N2O3S, used to treat type 2 diabetes.

tolbutamide

(tɒlˈbjuːtəˌmaɪd)
n
(Pharmacology) a synthetic crystalline compound administered orally in the treatment of diabetes to lower blood glucose concentrations. Formula: C12H18N2O3S
[C20: from tol(uyl) + but(yric acid) + amide]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tolbutamide - sulfonylurea; an oral antidiabetic drug (trade name Orinase) used in the treatment of adult-onset diabetes mellitus
sulfonylurea - antidiabetic consisting of any of several drugs that reduce the level of glucose in the blood; used to treat diabetes mellitus
hypoglycaemic agent, hypoglycemic agent - any of various agents that decrease the level of glucose in the blood and are used in the treatment of diabetes mellitus
References in periodicals archive ?
The first was tolbutamide under the trade name Orinase from Upjohn Co.
Six drugs are included in this subclass: chlorpropamide, glimepiride (Amaryl), glipizide (Glucotrol), glyburide, tolazamide (Tolinase), and tolbutamide.
Multicenter, placebo-controlled trial comparing acarbose (BAY g 5421) with placebo, tolbutamide, and tolbutamide-plus-acarbose in non-insulin-dependent diabetes mellitus The American Journal of Medicine, 98(5), 443-451.
D-xylose transport in isolated skeletal muscle of chickens: Effects of insulin and tolbutamide.
islets (Figure 8A and B) [88], however, the total insulin secretion by 30 mM KCl (Figure 8A) [88], glucose-induced (25 mM) changes of ATP/ADP ratio (Figure 8C) [85,88] and insulin secretion in response to 10 mM KIC and 25 mM tolbutamide were compatible in both [Bad.
However, these drugs themselves raise the gastric pH leading to the decrease in absorption of cefpodoxime, while increasing the absorption of [beta]-blockers and tolbutamide.
Modifications of antidiabetic drugs in patients with type 2 diabetes mellitus (adapted from the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines) Class Drug Dosing recommendation stages 3 and 4 CKD or kidney transplant First-generation Acetohexamide, Avoid sulfonylureas tolazamide, tolbutamide Chlorpropamide Avoid when GFR < 50 mL/min/ 1.
Streptozotocin (STZ), glibenclamide (GB), tolbutamide (TB), collagenase V and bovine serum albumin (BSA) were obtained from Sigma (St.
Tolbutamide can be obtained by the isosteric replacement of NH 2 by CH 3 group in carbutamide.
insulin, tolbutamide, phenformin, troglitazone, rosigitazone and repaglinide, are the mainstay of diabetes treatments and are effective in controlling hyperglycemia.