[27.] Seki Y, Kan S, Akiba Y Changes in muscle mrnas for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide
Inclusion complexation of tolbutamide
with [beta]-cyclodextrin and hydroxypropyl-[beta]-cyclodextrin.
In addition, a flexible-dose clinical study carried out at three different diabetic centers on 172 subjects found 86% of subjects given Pterocarpus extract (2-4 grams/day) showed glycemic control and was comparable to the activity of Tolbutamide
(0.75-1.5 grams/day) (Diabetoiogia Croatia, 2005).
This was done in comparison with the standard oral antidiabetic drug, tolbutamide
. Three groups of normal albino rats were chosen with 6 rats in each group.
Studies of tolbutamide
, another sulfonylurea, show that it can increase blood insulin concentrations in normal chickens and decrease blood glucose concentrations even in pancreatectomized chickens.
Many drugs, including the anti-diabetic drugs, glyburide and tolbutamide
, are also known obesogens.
Calendula syrup 10% Anti-inflammatory, Ibuprofen, naproxen, antiviral, blood piroxicam, venaton tonic, antipsasmodic drops, pahomin drops Santa Cana syrup 10% Antipyretic, Dipyrone, diuretic, paracetamol, pahomin antioxidant, drops antispasmodic Guava tincture 20% Antidiarrhoeal, Rehydrating salts, antispasmodico, pahomin drops, sedative, haemolytic chlordiazepoxide Guava powder, Antibacterial, Triamcinolone, chamomile flowers fungicidal ketoconazole, tolnaftate, micocilen ointment Chamomile cream Antibacterial, anti- Triamcinolone, inflammatory, ketoconazole, antiseptic, tolnaftate, antioxidant micocilen ointment, clobestasol cream Chilean Little Hypoglycaemic Glibenclamide, Rosemary liquid tolbutamide
, extract glibepiridine.
Substances with Potential to Interfere with Blood Glucose Results Acetaminophen (Tylenol[R]) Ascorbic acid Conjugated bilirubin Unconjugated bilirubin Cholesterol Creatinine 3,4-dihydroxyphenethylamine (dopamine) Ethylenediaminetetraacetic acid (EDTA) (Versene[R]) Galactose Gentisic acid (gentisate) Reduced glutathione Hemoglobin Heparin* Ibuprofen (Motrin[R]) Icodextrin (Extraneal[R]) L-dopa (levodopa) Maltose Methyldopa (Aldomet[R]) Salicylic acid Sodium Tolbutamide
(Orinase[R]) Source: FDA, 2016 * Inclusion of EDTA and heparin in this table refers to their use as therapeutic substances and not as anticoagulants for sample preparation.
The drugs were categorized into 5 distinct groups: metformin, glyburide, thiazolidinediones (pioglitazone, rosiglitazone), insulin and other oral hypoglycemic agents (chlorpropamide, gliclazide, tolbutamide
, glimepiride, sitagliptin, saxagliptin, nateglinide, repaglinide).
For determining the safety of clinical combination use, the influences of oldenlandia diffusa on the activities of five CYP450 subtypes in rats is evaluated according to the pharmacokinetic parameters changes using five specific probe drugs (phenacetin for CYP1A2, omeprazole for CYP2C19, tolbutamide
for CYP2C9, metoprolol for CYP2D6, and midazolam for CYP3A4); compare oldenlandia diffusa-treated groups with control group.
Remko  used the methods of theoretical chemistry to elucidate the molecular properties of the hypoglycemic sulfonylureas and glinides (acetohexamide, tolazamide, tolbutamide
, chlorpropamide, gliclazide, glimepiride, glipizide, glibenclamide, nateglinide, and repaglinide) which are known as antidiabetic molecules.
Raye, "Response of the fetal and newborn lamb to glucose and tolbutamide
infusions," Pediatric Research, vol.