tolbutamide


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Related to tolbutamide: acarbose, metformin

tol·bu·ta·mide

 (tŏl-byo͞o′tə-mīd′)
n.
A sulfonylurea drug, C12H18N2O3S, used to treat type 2 diabetes.
[tol(u) + but- + amide.]

tolbutamide

(tɒlˈbjuːtəˌmaɪd)
n
(Pharmacology) a synthetic crystalline compound administered orally in the treatment of diabetes to lower blood glucose concentrations. Formula: C12H18N2O3S
[C20: from tol(uyl) + but(yric acid) + amide]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tolbutamide - sulfonylurea; an oral antidiabetic drug (trade name Orinase) used in the treatment of adult-onset diabetes mellitus
Orinase
sulfonylurea - antidiabetic consisting of any of several drugs that reduce the level of glucose in the blood; used to treat diabetes mellitus
hypoglycaemic agent, hypoglycemic agent - any of various agents that decrease the level of glucose in the blood and are used in the treatment of diabetes mellitus
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References in periodicals archive ?
The first was tolbutamide under the trade name Orinase from Upjohn Co.
The Treatment of Diabetes: A Brief History
Six drugs are included in this subclass: chlorpropamide, glimepiride (Amaryl), glipizide (Glucotrol), glyburide, tolazamide (Tolinase), and tolbutamide.
Safety of oral antidiabetic agents in pregnancy
Multicenter, placebo-controlled trial comparing acarbose (BAY g 5421) with placebo, tolbutamide, and tolbutamide-plus-acarbose in non-insulin-dependent diabetes mellitus The American Journal of Medicine, 98(5), 443-451.
A non-linear mixed-effects model to describe the effect of acarbose intake on postprandial glycaemia in a single rat/Um modelo nao linear de efeitos mistos para descrever o efeito da ingestao de acarbose na glicemia pos-prandial em um unico rato
D-xylose transport in isolated skeletal muscle of chickens: Effects of insulin and tolbutamide.
Peripheral insulin doesn't alter appetite of broiler chicks
islets (Figure 8A and B) [88], however, the total insulin secretion by 30 mM KCl (Figure 8A) [88], glucose-induced (25 mM) changes of ATP/ADP ratio (Figure 8C) [85,88] and insulin secretion in response to 10 mM KIC and 25 mM tolbutamide were compatible in both [Bad.
Apoptosis in pancreatic [beta]-islet cells in Type 2 diabetes
The effect of tolbutamide on lipoproteins and lipoproteinlipase and hormone sensitive lipase.
Duration effect of Acacia nilotica leaves extract and glibenclamide as hypolipidaemic and hypoglycaemic activity in alloxan induced diabetic rats
However, these drugs themselves raise the gastric pH leading to the decrease in absorption of cefpodoxime, while increasing the absorption of [beta]-blockers and tolbutamide.
Drug interaction and its implication in clinical practice and personalized medicine
Modifications of antidiabetic drugs in patients with type 2 diabetes mellitus (adapted from the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines) Class Drug Dosing recommendation stages 3 and 4 CKD or kidney transplant First-generation Acetohexamide, Avoid sulfonylureas tolazamide, tolbutamide Chlorpropamide Avoid when GFR < 50 mL/min/ 1.
Important causes of chronic kidney disease in South Africa
Streptozotocin (STZ), glibenclamide (GB), tolbutamide (TB), collagenase V and bovine serum albumin (BSA) were obtained from Sigma (St.
Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro
Tolbutamide can be obtained by the isosteric replacement of NH 2 by CH 3 group in carbutamide.
Input of Isosteric and Bioisosteric Approach in Drug Design
insulin, tolbutamide, phenformin, troglitazone, rosigitazone and repaglinide, are the mainstay of diabetes treatments and are effective in controlling hyperglycemia.
EFFECT OF PLEUROTUS CITRINOPILEATUS ON BLOOD GLUCOSE, INSULIN AND CATALASE OF STREPTOZOTOCIN-INDUCED TYPE 2 DIABETES MELLITUS RATS
The permissive effect of glucose, tolbutamide and high [K.
Pancreatic islets isolated from [[beta].sub.2] adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients/Ilhotas pancreaticas isoladas de camundongos com delecao do receptor adrenergico [[beta].sub.2] apresenta reduzida secrecao de insulina em resposta a nutrientes

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