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Related to tophaceous: tophaceous gout


a. tofacio, rel. a un tofo o de naturaleza arenosa.
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We report the first case of bilateral knee arthroplasty in a patient with both articular and subcutaneous tophaceous gout.
Caption: 'When I see patients with tophaceous gout, my target is never 6 [mg/dl].
M2 EQUITYBITES-January 9, 2013-Savient Pharmaceuticals Inc's KRYSTEXXA approved in the EU for chronic tophaceous gout(C)2013 M2 COMMUNICATIONS
The agency has issued a positive opinion recommending approval of a marketing authorisation in the European Union for KRYSTEXXA for the treatment of severe debilitating chronic tophaceous gout in adult patients who may also have erosive joint involvement and who have failed to normalise serum uric acid with xanthine oxidase inhibitors at the maximum medically appropriate dose, or for whom these medicines are contraindicated.
For patients with severe cases of tophaceous gout or those who can't tolerate the other medications, the drug pegloticase (Krystexxa), given as an infusion, may be an option.
Multiple tophaceous deposits, grayish discoloration, and hallux valgus deformity were noted on the great toe on both sides.
Gout can progress through four stages: asymptomatic hyperuricemia--uric acid levels are high, but no symptoms occur (only one-third of people with this type actually develop gout); acute gout--the sudden onset of intense pain, swelling, and tenderness; interval gout--the period between acute attacks; and chronic tophaceous gout--can develop over many years and produce crystal deposits called tophi in the joints, bones, and cartilage (most people will never reach this stage).
The histopathological examination revealed a chronic granulomatous inflammation with debris and deposition of urate crystals indicating tophaceous gout, with no signs of any malignancy.
Intratendinous tophaceous gout imitating patellar tendonitis in an athletic man.
They applied the ACR working case scenarios and grouped patients by increasing level of disease severity Patients in the scenarios 1-3 group had intermittent symptoms and no tophi (mild disease); patients in the scenarios 4-6 group had intermittent symptoms and 1 tophus or more (moderate disease), and patients in the scenarios 79 group had chronic tophaceous gouty arthropathy (more severe disease).
The ACR effort addressed four specific domains of gout management: treatment of acute gouty attacks, management of urate-lowering therapy, management of chronic tophaceous gout, and prophylaxis of acute gouty attacks.
For patients on dual oral therapy at maximum acceptable doses who were still having frequent flares or those with unresolving chronic tophaceous arthropathy, the TFP recommended pegloticase.