tophus

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to·phus

 (tō′fəs)
n. pl. to·phi (-fī)
1. A deposit of urates in the skin and tissue around a joint or in the external ear, occurring in gout. Also called chalkstone.
2. A concretion of mineral salts and organic matter deposited on the surface of the teeth.

[Latin tōphus, tufa.]

tophus

(ˈtəʊfəs)
n, pl -phi (-faɪ)
(Pathology) pathol a deposit of sodium urate in the helix of the ear or surrounding a joint: a diagnostic of advanced or chronic gout. Also called: chalkstone
[C16: from Latin, variant of tōfus tufa, tuff]
tophaceous adj

to•phus

(ˈtoʊ fəs)

n., pl. -phi (-fī).
a calcareous concretion formed in the soft tissue about a joint, in the pinna of the ear, etc., esp. in gout.
[1545–55; < Latin tōphus, tōfus tufa]
to•pha•ceous (təˈfeɪ ʃəs) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tophus - a deposit of urates around a joint or in the external eartophus - a deposit of urates around a joint or in the external ear; diagnostic of advanced or chronic gout
urate - a salt of uric acid
2.tophus - an incrustation that forms on the teeth and gumstophus - an incrustation that forms on the teeth and gums
crust, encrustation, incrustation - a hard outer layer that covers something
Translations

to·phus

n. tofo.
1. depósito de sal de ácido úrico en los tejidos, gen. visto en casos de gota;
2. cálculo dental.

tophus

n (pl -phi) tofo
References in periodicals archive ?
In chronic recurrent attacks of gout, patients may manifest with affection of the upper limb joints and the formation of tophi.
Of those with a tophus at baseline, 6 (16%) of 37 of the control/DE group and 4 (13%) of 31 of the DE/ DE group had complete resolution of all tophi between months 12 and 24.
Furthermore, multifocal gout tophi were observed in the parenchyma and the serosa of the liver, heart, and kidneys, consistent with visceral and renal gout.
On microscopic evaluation of the specimen, the sections stained with hematoxylin and eosin demonstrated degenerative osteochondrotic tissue and some amorphous material surrounded by multinucleated giant cells compatible with tophi in the soft tissue [Figure 4].
4 mg/dL) is now recommended after some years of successful ULT when tophi (deposits of uric crystal acids under the skin or in a joint) have resolved and the patient remains symptom-free.
7) Tophi typically present within subcutaneous tissue, joints, tendons, and ligaments, and have been implicated in the development of structural joint damage.
One study (Characterization of Patients with Chronic Refractory Gout Who Do and Do Not Have Clinically Apparent Tophi: Response to Pegloticase; abstract THU0448) retrospectively analyzed data from two pivotal, six-month, randomized clinical trials comparing patients with and without clinically apparent tophi, which are hard uric acid deposits under the skin that contribute to bone and cartilage destruction.
Managing serum urate levels is the cornerstone of treating gout, and international guidelines recommend targets of less than 6 mg/dL, or less than 5 mg/dL in the presence of tophi.
Tophi occur as a result of urate crystals that precipitate into joints and surrounding tissues.
Ultrasound may also be useful in identifying possible underlying causes such as rheumatoid nodules and gouty tophi.
6) The ARA criteria for gout diagnosis require either tophi or monosodium urate crystals in synovial fluid, or 6 out of a list of 12 other criteria.
Although not rare, carpal tunnel syndrome (CTS) caused by gouty tophi is still uncommon according to the literature, (3) and its presence indicates the severity of untreated gouty tophi.