topoisomerase


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Related to topoisomerase: DNA gyrase

to·po·i·som·er·ase

 (tō′pō-ī-sŏm′ə-rās′, -rāz′)
n.
Either of two isomerase enzymes that alter the topology of DNA molecules by breaking and reconnecting coiled strands.

topoisomerase

(ˌtɒpəʊaɪˈsɒməreɪs)
n
(Biochemistry) biochem any of a class of enzymes that control the coiling of DNA molecules
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References in periodicals archive ?
The case of topoisomerase inhibitors is unusual in that these drugs have gone through the entire approval process for cancer.
The flavonoids fight an enzyme - known as human DNA topoisomerase II - that is crucial to the spread of cancer cells.
Besides his administrative and teaching activities, DiGate is known for his research on the role of DNA topoisomerases in DNA replication and the design and synthesis of topoisomerase inhibitors.
Also molecular property screening methods, including a preferred method, termed end selection, comprised of using an enzyme, such as a topoisomerase, a restriction endonuclease, &/or a nicking enzyme (such as N.
Xanafide (amonafide malate) is an ATP-independent topoisomerase 2 inhibitor.
"The finding that they improve the anti-cancer activity of topoisomerase 1 poisons indicates they may be useful in treatment of bowel cancer."
Some powerful antibiotics and key anti-cancer drugs act by inhibiting topoisomerases. In cancer, cells rapidly divide in an uncontrolled manner and topoisomerase inhibitors can block this uncontrolled cell division.
The test, TOP2A FISH pharmDx, examines topoisomerase 2-alpha (TOP2A) genes in tumor tissue that has been surgically removed from the breast via lumpectomy or mastectomy.
Ribonuclease activity of vaccinia DNA topoisomerase IB: kinetic and high-throughput inhibition studies using a robust continuous fluorescence assay.
Researchers have been looking at how cancer cells react when given PARP inhibitors alongside a type of chemotherapy called Topoisomerase 1 poisons, which is used to treat bowel cancer, a very common form of the disease.
Topoisomerase II alpha amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013.
Characterization of DNA topoisomerase I from Candida albicans as a target for drug discovery.