It is commonly associated with antibiotic use and the life-threatening complications include pseudomembranous colitis, toxic megacolon
, perforation of the colon and death.
CLENPIQ is contraindicated in the following conditions: patients with severe renal impairment (creatnine clearance less than 30mL/minute), gastrointestinal obstruction or ileus, bowel perforation, toxic colitis or toxic megacolon
, gastric retention, or in patients with a known hypersensitivity to any of the ingredients in CLENPIQ.
difficile) is a spore-forming pathogen that typically causes symptoms in individuals with altered gut microbial flora, releasing toxins that can result in a range of disease manifestations from asymptomatic colonization to diarrhea, pseudomembranous colitis, toxic megacolon
, intestinal perforation, or, in the most severe cases, death.
Rates of toxic megacolon
were equal (7% each group); ileus was more frequent in the tigecycline group (11% vs.
Surgery is generally reserved for patients with intractability, colorectal cancer, toxic megacolon
, massive bleeding or perforation.
His abdomen was distended and he had toxic megacolon
In its most extreme form it is capable of causing colitis, toxic megacolon
, and death.
CDI is a disease of the large intestine, and the severity ranges from uncomplicated diarrhea to severe colitis that can result in life-threatening toxic megacolon
If undiagnosed or untreated, pseudomembranous colitis, toxic megacolon
and death may result.
Clinically, the patient with toxic megacolon
will develop marked colonic distention, peritoneal irritation, fever, and leukocytosis.
difficile can lead to sepsis (inflammation throughout the body that can cause organ failure), acidosis (a high acid level in body fluids), tachycardia (rapid heartbeat), colonic perforation (a hole in the colon wall), and toxic megacolon
(a widened or dilated colon that receives inadequate blood flow); diarrhea can actually lessen in severe disease.
Four contracted diarrhoea; three of which had negative stool cultures but one was positive for clostridium difficile, developed toxic megacolon