Toxicogenomics: Technologies for Identifying Biomarkers of Toxicity
It has become clear that a global systems model is a more accurate way of viewing toxicity
Later, when each of the 18 participants received a standard dose of amonafide, signs of drug-related toxicity
emeged in the same seven people, including three who responded with a severe decline in white blood cells, Ratain says.
In addition, we believe our carbohydrate technology can lower the toxicity
of effective, but highly toxic drugs and/or increase their half life.
We agree that analysis of mixtures toxicity
using concentration addition requires an understanding of the toxicity
of the individual constituents within a mixture.
Scientists suspect this vessel constriction is the basis for the observed kidney toxicity
The pharmacokinetic (PK) results show that 5-FU, in combination with DAVANAT([R]), remained significantly longer in the bloodstream (up to 8 times), without increasing 5-FU's toxicity
in these fragile patients.
If one were to also assume the resident is maximally exposed to these contaminants via consumption, inhalation, and dermal pathways, then the toxicity
threat can appear more extreme than it likely is among most individuals.
The symposium attracted more than 200 university and industry researchers, government regulators and private citizens to provide an update on the status of in vitro skin and eye toxicity
There was little bone marrow toxicity
and no hemorrhagic cystitis (bladder toxicity
) or CNS toxicity
2004), SRM 2975 had not been used in many pulmonary toxicity
studies, and the automobile-generated DEP (ADEP) had not been tested for genotoxicity.
On the other hand, he says, referring to the new findings of liver toxicity
, "I'm glad we had only 50 or so patients in this trial, and not 50,000.