toxin-antitoxin


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tox·in-an·ti·tox·in

(tŏk′sĭn-ăn′tĭ-tŏk′sĭn)
n.
1. A pair of genes that encode a stable, toxic protein and a corresponding unstable antitoxin that is either a protein or RNA, found in many bacteria either on a plasmid or on the bacterial chromosome.
2. A mixture of a toxin and its antitoxin with a slight excess of toxin, formerly used as a vaccine.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

toxin-antitoxin

n
(Pharmacology) a mixture of a specific toxin and antitoxin. The diphtheria toxin-antitoxin was formerly used in the US for active immunization
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
In bacterial and archaeal genome toxin-antitoxin (TA) complex is evident [1].
Especially, recent biological study has confirmed that the signaling nucleotide (p)ppGpp can control bacterial persistence by stochastic induction of toxin-antitoxin activity, and there is a special resistant strain, which can switch into slow growth through the changes of (p)ppGpp level in high antibiotic concentration [5].
In 1922, the Citizens Medical Reference Bureau published a pamphlet titled Protest Against Sending Nurses Into Homes of School Children to Urge Medical Treatment, and Against Using Public Schools to Promote the Schick Test, and Toxin-Antitoxin. "While in some cases a nurse may be modest in her statements," the group claimed, "in other cases where a nurse is overenthused about having a child treated, statements are sure to be made which are uncalled for" (Anderson, 1922).
In 1913 German researcher Emil Behring first injected toxin-antitoxin into humans to create an immunity to diphtheria over time.
A strain of Corynebacterium ulcerans was subsequently isolated from the culture specimen at CDC, and toxin production by this strain was confirmed by a toxin-antitoxin precipitation assay (Elek test) and by PCR assay on the isolate.