The team tested six different HIV reverse transcriptase
inhibitors to see if they could block L1 activity and the interferon response.
Merck announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion recommending granting of marketing authorization for two HIV-1 medicines: DELSTRIGO, a once-daily fixed-dose combination tablet of doravirine (100 mg), lamivudine (3TC, 300 mg) and tenofovir disoproxil fumarate; and PIFELTRO (doravirine, 100 mg), a new non-nucleoside reverse transcriptase
inhibitor (NNRTI) to be administered in combination with other antiretroviral medicines.
It was reported on Friday that the trials, named GEMINI-1 and GEMINI-2, evaluated the 2DR against a three-drug regimen of dolutegravir and two nucleoside reverse transcriptase
inhibitors in HIV-1 patients with baseline viral loads under 500,000 copies per ml.
Summary: Quantitative structure-activity relationships were constructed for 107 inhibitors of HIV-1 reverse transcriptase
that are derivatives of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
The pooled, open-label study reported on 1,028 individuals who met a base criteria of stable viral suppression (viral load fewer than 50 copies/mL) by a first or second CAR regimen consisting of two nucleoside reverse transcriptase
inhibitors (NR-TIs) plus a third drug (nonnucleoside reverse transcriptase
inhibitors, integrase strand transfer inhibitors, or a protease inhibitor) for a minimum of 6 months at time of screening.
The alteration occurs in the telomerase reverse transcriptase
gene, which helps to produce the enzyme telomerase.
This family of viruses uses molecular machinery called reverse transcriptase
Researchers from the Republic of Korea isolated a population of stem cells derived from dental tissues of third molars and found that human dental papilla stem cells--DpaSCs that develop into dentin and dental pulp--have biological features similar to bone marrow-derived mesenchymal stem cells (MSCs) in terms of telomere length, telomerase activity and reverse transcriptase
Rifampicin, a key component of TB treatment, is a potent inducer of drug metabolism and decreases plasma concentrations of many co-administered drugs, including non-nucleoside reverse transcriptase
inhibitors, protease inhibitors and integrase inhibitors.
Thermo Fisher Scientific, the world leader in serving science, have announced that the DuPont Qualicon BAX[R] System Reverse Transcriptase
8-hour Listeria Assay is now available alongside the Oxoid range in Europe, Canada, Australia and New Zealand.
It inhibited HIV-1 reverse transcriptase
with [IC.sub.50] of 0.23 [mu]M.