However, about 20% of the mRNA can be "translationally
" inhibited by miRNAs without significant degradation .
As NPCs have the potential for the treatment of different disorders and neurotrauma in the nervous system, it is critical to use translationally
related approaches to direct NPCs towards a specific phenotype.
(i) The [Ca.sup.2+] sensitivity of CV-CV and CV-PM fusion are comparable, with submaximal responses to [Ca.sup.2+] (i.e., there is a distribution of [Ca.sup.2+] sensitivities across the population of CV) that follow a sigmoidal pattern (Knight and Scrutton, 1986; Knight and Baker, 1987; Vogel et al., 1996; Blank et al., 1998a, b, 2001; Coorssen et al., 1998); these responses are comparable to and translationally
invariant relative to those of other secretory cells (Knight and Scrutton, 1986), and indeed similar responses are seen in mammalian CNS neurons (Wolfel et al..
Thus, benefitial effects of propolis in male tumor-bearing mice treated with 5FU might be explained by increased sensitivity to 5FU as the result of translationally
This suggests p120 levels are translationally
regulated, as has been shown for other proteins important in development [e.g., sea urchin tubulin, (38) and tetkin A (39)].
(8) reported that sequencing of the CK-M cDNA from the skeletal muscle of an individual with DM revealed two novel polymorphisms but no translationally
controlled tumor protein (TCTP) was initially described as an abundant growth-related (Yenofsky et al., 1983) and highly conserved 19-kDa protein (Thaw et al.,7 2001).
Storch and Portner (2003) reported similar costs of protein synthesis for translationally
active cell-free homogenates prepared from gills of adult Antarctic scallops when compared to homogenates from European scallops.
regulated mRNAs are stored in the cytoplasm of clam oocytes.
Ampakines also have demonstrated positive activity in animal models of ADHD, results that have been extended translationally
into statistically significant improvement of symptoms observed in a Phase 2 clinical trial of CX717 in adults with ADHD.