INBRIJA is not to be used by patients who take or have taken a nonselective monoamine oxidase inhibitor such as phenelzine or tranylcypromine
within the last two weeks.
Clonidine potentiates the effects of tranylcypromine
, phenelzine and two analogues in the forced swimming test in mice.
The use of Fluoxetine along with Tranylcypromine
in patients with bipolar affective disorder, cause an interaction that exacerbates maniac episodes and induce Serotoninergic Syndrome.
The National Pregnancy Registry for Antidepressants (844-405-6185) is studying amitriptyline (Elavil), amoxapine (Asendin), bupropion (Forfivo XL and Wellbutrin), Citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), desvenlafaxine (Prisiq), doxepin (Sinequan), escitalopram (Lexapro), fluvoxamine (Luvox), fluoxetine (Prozac), imipramine (Tofranil), isocarboxazid (Marplan), levomilnacipran (Fetzima), maprotiline (Ludiomil), mirtazapine (Remeron), nefazodone (Serzone), nortriptyline (Pamelor), paroxetine (Paxil), phenelzine (Nardill), protriptyline (Vivactil), selegiline (Emsam), sertraline (Zoloft), tranylcypromine
(Parnate), trazodone (Desyrel), trimipramine (Surmontil), venlafaxine (Effexor), and vilazodone (Viibryd).
Additionally, MAO inhibitors, such as clorgiline, phenelzine, moclobemide and tranylcypromine
, which are used to treat depression, and anticholinergics, such as scopolamine, biperidene, trihexyphenydil and benztropine, have some serious potential to increase mood and physical resistance, very similar to amphetamines.
Edema has been reported during treatment with various antidepressants such as mirtazapine, trazodone, tranylcypromine
, phenelzine and isocarboxazid (13-15).
- MAOIs: Tranylcypromine
and phenelzine have been involved in oral abuse due to their amphetamine-like structure; series of cases have been reported in particular with tranylcypromine
The pharmacodynamic properties of majority of anti-depressants and lack of sudden desirous dependency makes addiction less likely, so it is inferred that apart from tranylcypromine
and amineptine, antidepressants have inadequate accountability to germ depression.
Some like Valium, Proscar, tranylcypromine
, amitriptyline, and their relatives have been extensively used and can be considered "over-the-counter" drugs.
The antidepressants tested in the first series of studies aimed to examine their effects on the production of neurons in the adult rat brain included a MAO inhibitor: tranylcypromine
, an SSRI: fluoxetine, and an NRI: reboxetine, as well as electroconvulsive seizures.
For the past 12 years, he had been seen as an outpatient in a psychiatry clinic where medication trials included citalopram, fluoxetine, venlafaxine, reboxetine, phenelzine, tranylcypromine
, mirtazapine, lamotrigine, perphenazine, and diazepam.
Chronic treatment with various antidepressants like tranylcypromine
, reboxetine, fluoxetine, and haloperidol is reported to increase neurogenesis in early adulthood and experimental models of stress .