and phenelzine have been involved in oral abuse due to their amphetamine-like structure; series of cases have been reported in particular with tranylcypromine
The pharmacodynamic properties of majority of anti-depressants and lack of sudden desirous dependency makes addiction less likely, so it is inferred that apart from tranylcypromine
and amineptine, antidepressants have inadequate accountability to germ depression.
Animal studies have determined that excessive stimulation of the 5HT2A receptor is primarily responsible for SS, (4) and that 5HT2A antagonists, such as mirtazapine, can block the development of SS in a mouse coadministered fluoxetine and tranylcypromine
8 SGB V to products containing the substance tranylcypromine
(ATC code N06AF04) as part of a so-called open-house model.
Medications used for depression include phenelzine (Nardil), tranylcypromine
(Parnate), and others.
Hyphantis, "NAcetylcysteine augmentation to tranylcypromine
in treatmentresistant major depression," Journal of Clinical Psychopharmacology, vol.
Several studies found an inhibitory effect of [alpha]-naphthoflavone, ketoconazole, troglitazone, tranylcypromine
, ebastine, and terfenadine on the rate of astemizole O-demethylation in human small intestinal microsomes and recombinant CYP2J2 isoform (Matsumoto et al.
yogurt, sour cream, beef or chicken liver, salami, Names: phenelzine, pepperoni, avocados, bananas, tranylcypromine
canned figs, dried fruits (raisins, prunes), raspberries, sauerkraut, soy beans, soy sauce, fava beans, and chocolate.
blocks the activity of LSD1, a protein found in humans and other mammals.
However, data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study  did not find significantly increased remission rates of patients taking the mirtazapine plus venlafaxine combination versus those on monotherapy with tranylcypromine
2) Monamine Oxidase Inhibitors (MAOIs): They were also the first medications used to treat "Reactive Depression" and include Phenelzine (Nardil), Selegiline (Emsam) and Tranylcypromine
Phenelzine and tranylcypromine
are irreversible inhibitors of the monoamine oxidase enzyme (MAO).