Devimistat is designed to target the mitochondrial tricarboxylic
acid (TCA) cycle, a process essential to tumor cell multiplication and survival, selectively in cancer cells.
It is comprised of an aqueous continuous phase of one or more polyhydroxy acid lactones; one or more aliphatic di- or tricarboxylic
acids; and of glyoxylic acid or a salt or hydrate thereof.
Exhaustive exercise significantly increased the tricarboxylic
acid cycle (TCA) intermediates levels including citric acid, fumaric acid and butanedioic acid in male rats.
Many of these organic acids with higher accumulation are intermediates of the tricarboxylic
acid (TCA) cycle of respiration, including citric acid and malic acid.
NA[D.sup.+] is an essential compound in the body; it is required for normal mitochondrial function, energy production from the tricarboxylic
acid (TCA) cycle, and fatty acid oxidation.
Influence of environmental and nutritional factors on succinic acid production and enzymes of reverse tricarboxylic
acid cycle from Enterococcus flavescens.
Some research has found that TPM was able to inhibit the mitochondrial zinc enzyme carbonic anhydrase-V, resulting in tricarboxylic
cycle dysfunction and severe lactic acidosis., However, in a pilocarpine model, TPM showed a neuroprotective effect. The recommendations for the treatment of myoclonic seizures in mitochondrial diseases are controversial., Currently, it is considered less effective to use monotherapy, and a combinatory approach for myoclonic seizures treatment is recommended.
Succinate dehydrogenase (SDH) is the key enzyme that converts succinate to fumarate in the tricarboxylic
acid cycle, and it is composed of 4 subunits: SDHA, SDHB, SDHC, and SDHD.
The concentrations of the acids were 0.1356, 0.0678 and 0.0452 M for monocarboxylic acids (acetic acid), dicarboxylic acids (malic, tartaric, malonic, oxalic and succinic acids) and tricarboxylic
acids (citric acid), respectively.
Succinate dehydrogenase consists of four protein subunits: SDHA to SDHD that are localized in the inner mitochondrial membrane and act at the interphase of the tricarboxylic
acid cycle and electron transport chain.
A soluble NADH-dependent fumarate reductase in the reductive tricarboxylic
acid cycle of Hydrogenobacter thermophilus TK-6.
The concentrations of tricarboxylic
acid (TCA)-related metabolites, such as malic acid, ketoglutaric acid, succinic acid, fumaric acid, citric acid, and oxalacetic acid, were significantly changed in the HS group compared with the non-HS group, with concentrations of the first four metabolites decreased 0.50- to 0.62-fold (p<0.01) and those of the last two metabolites increased 1.37- and 1.78-fold (p<0.05), respectively.