Hermosa et al., "Identification of loci and functional characterization of trichothecene
biosynthesis genes in filamentous fungi of the genus Trichoderma" Applied and Environmental Microbiology, vol.
Production of trichothecene
mycotoxins by Fusarium graminearum and Fusarium culmorum on barley and wheat.
mycotoxins are a group of toxic secondary metabolites characterized by the tetracyclic 12, 13-epoxy trichothecenes
, since they all have an olefinic bond at C9, 10 and the epoxy ring at C12,13 (Bamburg et al.
Samples contained the potent protein synthesis inhibitor Satratoxin H, a member of the Trichothecene
mycotoxin group that causes immunosuppression.
The toxin, called T-2 toxin, is a trichothecene
that is a natural contaminant of food and livestock feed.
Wan et al  revealed that due to trichothecene
toxicity, IGFBP4, an insulin-like growth factor (IGF)-binding protein, was suppressed in the rat pituitary adenoma gretchen hagen 3 (GH3) cells, demonstrating that the T-2 toxin gave rise to a growth hormone-IGFBP4 deficiency in the cells.
Stachybotrys chartarum, trichothecene
mycotoxins, and damp building-related illness: new insights into a public health enigma.
Similar ribosomal RNA injuries have been observed during nonprotein ribosome-inactivating stress triggered by physical and chemical insults such as ultraviolet (UV) irradiation, trichothecene
mycotoxins (mostly cereal contaminants produced by molds such Fusarium species), palytoxin (an intense vasoconstrictor produced by marine species including dinoflagellate Ostreopsis ovata), and anisomycin (an antibiotic produced by Strep tomyces griseolus), which also interfere with peptidyltrans ferase activity by directly or indirectly modifying 28s rRNA [11, 12].
Genetic population structure and trichothecene
genotypes of Fusarium graminearum isolated from wheat in southern Brazil.
Effect of the trichothecene
mycotoxin diacetoxyscirpenol on fertility and hatchability of broiler breeders.
Yatawara (1986), "Airborne Outbreak of Trichothecene
Toxicosis," Atmospheric Environment, 20:549-552.
They have successfully disarmed the fungus' ability to produce its toxin, trichothecene
, by identifying the gene that is responsible for the production of an enzyme, trichodiene synthase.