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 (trī-sĭk′lĭk, -sī′klĭk)
Having or being a molecular structure that contains three closed rings: a tricyclic molecule.
A tricyclic antidepressant drug.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Chemistry) (of a chemical compound) containing three rings in the molecular structure
(Pharmacology) an antidepressant drug having a tricyclic molecular structure
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(traɪˈsaɪ klɪk, -ˈsɪk lɪk)

1. pertaining to or embodying three cycles.
2. having a three-ring chemical structure.
3. Also called tricy′clic antidepres′sant. any of a group of pharmacologically active substances that share a common three-ring structure, used to treat depression and cocaine abuse.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tricyclic - an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain
amitriptyline, amitriptyline hydrochloride, Elavil - a tricyclic antidepressant drug (trade name Elavil) with serious side effects; interacts with many other medications
antidepressant, antidepressant drug - any of a class of drugs used to treat depression; often have undesirable side effects
clomipramine - a tricyclic antidepressant drug
desipramine - a tricyclic antidepressant drug that activates the psychomotor system
Adapin, doxepin, doxepin hydrochloride, Sinequan - a tricyclic antidepressant (trade names Adapin and Sinequan) with numerous side effects (dry mouth and sedation and gastrointestinal disturbances)
Imavate, imipramine, impramine hydrochloride, Tofranil - a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression
nortriptyline, Pamelor - a tricyclic antidepressant drug (trade name Pamelor) used along with psychotherapy to treat dysthymic depression; may interact dangerously if taken with other drugs
protriptyline - tricyclic antidepressant used to treat clinical depression
Surmontil, trimipramine - tricyclic antidepressant drug (trade name Surmontil) used to treat depression and anxiety and (sometimes) insomnia
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Tricyclic antidepressants are an example of this type of drug, as are anticonvulsants.
In a study comparing 38 depressed children receiving another tricyclic, imipramine, with controls on a placebo, Puig-Antich similarly found no advantage for the antidepressant drug.
Patients on mirtazapine (Remeron), reboxetine (Vestra), and quetiapine (Seroquel) displayed substantially less psychomotor impairment and scored substantially higher on the standardized tests of global driving ability used in Germany than did patients on tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), or venlafaxine (Effexor), Dr.
Off-label use of systemic therapies usually starts with tricyclic antidepressants, most often amitriptyline.
The analysis included patients who were treated with six different, selective serotonin reuptake inhibitors, including paroxetine (Paxil) and fluoxetine; two tricyclic antidepressants, amitriptyline and doxepin; and venlafaxine (Effexor), a selective norepinephrine reuptake inhibitor.
Desmopressin (DDAVP) and tricyclic drugs reduce the number of wet nights by 1 to 2 per week during treatment, although the effect is not sustained after treatment is finished (SOR: A, based on a SR of homogeneous RCTs).
A number of treatments are available for women with postpartum depressive disorder, including tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and hormone therapy.
Those currently taking an antianxiety drug with effects extending over several days (including Valium), a tricyclic antidepressant (the most commonly used group of drugs to treat depression) or an antipsychotic were substantially more likely to have had a hip fracture.
ISTANBUL, TURKEY -- The use of tricyclic antidepressants to treat depression and /or anxiety was associated with a sharply increased risk of metabolic syndrome, compared with other antidepressant classes in a large prospective Dutch cohort study.
In the selection of pharmacotherapy, a selective serotonin reuptake inhibitor (SSRI) would be the first choice for younger women or postmenopausal women on hormone therapy, while a tricyclic antidepressant may be more effective in men and older women not taking hormones, said Dr.
Most patients with diabetic peripheral neuropathic pain will experience significant relief and improved quality of life when treated with tricyclic antidepressants, duloxetine, controlled-release oxycodone, pregabalin, or a combination of these agents, according to new treatment guidelines issued by the American Society of Pain Educators.
Tricyclic antidepressants, anticonvulsants, and capsaicin reduce the pain of diabetic neuropathy; limited data suggests that lidocaine patches may also be efficacious.