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 (trī-sĭk′lĭk, -sī′klĭk)
Having or being a molecular structure that contains three closed rings: a tricyclic molecule.
A tricyclic antidepressant drug.


(Chemistry) (of a chemical compound) containing three rings in the molecular structure
(Pharmacology) an antidepressant drug having a tricyclic molecular structure


(traɪˈsaɪ klɪk, -ˈsɪk lɪk)

1. pertaining to or embodying three cycles.
2. having a three-ring chemical structure.
3. Also called tricy′clic antidepres′sant. any of a group of pharmacologically active substances that share a common three-ring structure, used to treat depression and cocaine abuse.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tricyclic - an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain
amitriptyline, amitriptyline hydrochloride, Elavil - a tricyclic antidepressant drug (trade name Elavil) with serious side effects; interacts with many other medications
antidepressant, antidepressant drug - any of a class of drugs used to treat depression; often have undesirable side effects
clomipramine - a tricyclic antidepressant drug
desipramine - a tricyclic antidepressant drug that activates the psychomotor system
Adapin, doxepin, doxepin hydrochloride, Sinequan - a tricyclic antidepressant (trade names Adapin and Sinequan) with numerous side effects (dry mouth and sedation and gastrointestinal disturbances)
Imavate, imipramine, impramine hydrochloride, Tofranil - a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression
nortriptyline, Pamelor - a tricyclic antidepressant drug (trade name Pamelor) used along with psychotherapy to treat dysthymic depression; may interact dangerously if taken with other drugs
protriptyline - tricyclic antidepressant used to treat clinical depression
Surmontil, trimipramine - tricyclic antidepressant drug (trade name Surmontil) used to treat depression and anxiety and (sometimes) insomnia
References in periodicals archive ?
Annual spend - PS9,002,824 | Dosulepin - formerly known as dothiepin, it is a tricyclic antidepressant.
The results suggest that fluoxetine causes less bone resorption than other selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors, or tricyclic antidepressants and "may be a safer choice for a cohort already predisposed to poorer brain health," the researchers concluded in a poster presented at the 18th Congress of the International Psychogeriatric Association.
All of these findings suggest tricyclic antidepressant cardiotoxicity.
What is known is that tricyclic antidepressants, peppermint oil, and antispasmodics all have been shown superior to placebo for treating abdominal pain in female patients with irritable bowel syndrome (IBS) (strength of recommendation: A, meta-analyses).
Herein, I propose to develop rigid, tricyclic peptides that should, due to a more defined three-dimensional structure, bind to flat surfaces similar as antibodies.
Researchers looked at data on 9,200 people who were taking warfarin for atrial fibrillation (irregular heartbeat) and divided them into three groups: participants taking no antidepressants, those taking older tricyclic antidepressants, and those taking widely used newer selective serotonin reuptake inhibitors, or SSRIs.
Tittle: Pediatric Tricyclic Antidepressant Poisoning: Approach and Management
Compared directly with tricyclic antidepressants, SSRIs were associated with significantly higher rates of all-cause death (adjusted hazard ratio, 1.
One drug in the tricyclic group, trazodone, was associated with the highest absolute risk for all-cause death in the cohort (12.
Tricyclic drugs, which account for almost a third of all prescriptions for anti-depressants, cut the risk of bowel cancer by between 16% and 21%, according to a study.
What's in the news this week GOOD TrICYCLIC drugs - used regularly to treat depression and migraines - could also slash the risk of getting bowel cancer by up to 21 per cent, say experts from Lincoln University.
Tricyclic drugs, which account for almost a third of all antidepressants, cut the risk of bowel cancer by between 16 and 21per cent, the study found.