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 (trī-sĭk′lĭk, -sī′klĭk)
Having or being a molecular structure that contains three closed rings: a tricyclic molecule.
A tricyclic antidepressant drug.


(Chemistry) (of a chemical compound) containing three rings in the molecular structure
(Pharmacology) an antidepressant drug having a tricyclic molecular structure


(traɪˈsaɪ klɪk, -ˈsɪk lɪk)

1. pertaining to or embodying three cycles.
2. having a three-ring chemical structure.
3. Also called tricy′clic antidepres′sant. any of a group of pharmacologically active substances that share a common three-ring structure, used to treat depression and cocaine abuse.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tricyclic - an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain
amitriptyline, amitriptyline hydrochloride, Elavil - a tricyclic antidepressant drug (trade name Elavil) with serious side effects; interacts with many other medications
antidepressant, antidepressant drug - any of a class of drugs used to treat depression; often have undesirable side effects
clomipramine - a tricyclic antidepressant drug
desipramine - a tricyclic antidepressant drug that activates the psychomotor system
Adapin, doxepin, doxepin hydrochloride, Sinequan - a tricyclic antidepressant (trade names Adapin and Sinequan) with numerous side effects (dry mouth and sedation and gastrointestinal disturbances)
Imavate, imipramine, impramine hydrochloride, Tofranil - a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression
nortriptyline, Pamelor - a tricyclic antidepressant drug (trade name Pamelor) used along with psychotherapy to treat dysthymic depression; may interact dangerously if taken with other drugs
protriptyline - tricyclic antidepressant used to treat clinical depression
Surmontil, trimipramine - tricyclic antidepressant drug (trade name Surmontil) used to treat depression and anxiety and (sometimes) insomnia
References in periodicals archive ?
Herein, I propose to develop rigid, tricyclic peptides that should, due to a more defined three-dimensional structure, bind to flat surfaces similar as antibodies.
The clinical scenario of tricyclic antidepressant (TCA) overdose either alone or in combination with other drugs is not uncommon.
Tricyclic antidepressants (TCAs) are widely prescribed for several indications in South Africa.
Compared directly with tricyclic antidepressants, SSRIs were associated with significantly higher rates of all-cause death (adjusted hazard ratio, 1.
Tricyclic drugs, which account for almost a third of all prescriptions for anti-depressants, cut the risk of bowel cancer by between 16% and 21%, according to a study.
What's in the news this week GOOD TrICYCLIC drugs - used regularly to treat depression and migraines - could also slash the risk of getting bowel cancer by up to 21 per cent, say experts from Lincoln University.
Tricyclic drugs, which account for almost a third of all antidepressants, cut the risk of bowel cancer by between 16 and 21per cent, the study found.
A large population-based study has shown a link between tricyclic antidepressant medications and an increased risk of cardiovascular disease, adding to a growing body of evidence that the medications carry cardiovascular risks--both for people with and without existing disease.
The study that followed nearly 15,000 people in Scotland showed that tricyclic anti-depressants were associated with a 35pc increased risk of CVD, but that there was no increased risk with the newer anti-depressants such as the selective serotonin reuptake inhibitors (SSRIs).
Tests are available for the detection of amphetamine (1,000 ng/mL), barbiturates (300 ng/mL), benzodiazepines (300 ng/mL), uprenorphine (10 ng/mL), cocaine (300 ng/mL), Ecstasy (500 ng/mL), methadone (300 ng/mL), methamphetamine (1,000 ng/mL), opiates (300 ng/mL and 2,000 ng/mL), oxycodone (100 ng/mL), phencyclidine (25 ng/mL), propoxyphene (300 ng/mL), THC (50 ng/mL), and tricyclic antidepressants (1,000 ng/mL).
The women aged 19 to 42 years who participated were randomly assigned to either the tricyclic antidepressant nortriptyline (n=38) or the serotonin selective reuptake inhibitor sertraline (n=32).
The results of a study published in the July issue of Epidemiology suggest that long-term users of tricyclic antidepressants are at increased risk of non-Hodgkin's lymphoma (NHL).