tricyclic antidepressant


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tricyclic antidepressant

n. Abbr. TCA
Any of a group of antidepressant drugs, such as amitryptyline, that contain three fused benzene rings and that block the reuptake of the neurotransmitters norepinephrine and serotonin in the central nervous system.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tricyclic antidepressant - an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain
amitriptyline, amitriptyline hydrochloride, Elavil - a tricyclic antidepressant drug (trade name Elavil) with serious side effects; interacts with many other medications
antidepressant, antidepressant drug - any of a class of drugs used to treat depression; often have undesirable side effects
clomipramine - a tricyclic antidepressant drug
desipramine - a tricyclic antidepressant drug that activates the psychomotor system
Adapin, doxepin, doxepin hydrochloride, Sinequan - a tricyclic antidepressant (trade names Adapin and Sinequan) with numerous side effects (dry mouth and sedation and gastrointestinal disturbances)
Imavate, imipramine, impramine hydrochloride, Tofranil - a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression
nortriptyline, Pamelor - a tricyclic antidepressant drug (trade name Pamelor) used along with psychotherapy to treat dysthymic depression; may interact dangerously if taken with other drugs
protriptyline - tricyclic antidepressant used to treat clinical depression
Surmontil, trimipramine - tricyclic antidepressant drug (trade name Surmontil) used to treat depression and anxiety and (sometimes) insomnia
References in periodicals archive ?
In that paper, tricyclic antidepressants had a number needed to treat of 3.6, comparing favorably to 7.7 for pregabalin, 7.2 for gabapentin, and 6.4 for serotonin norepinephrine reuptake inhibitors, mainly including duloxetine, Dr.
Bicarbonate therapy for dysrhythmia and hypotension in tricyclic antidepressant overdose.
Gillman, "Tricyclic antidepressant pharmacology and therapeutic drug interactions updated," British Journal of Pharmacology, vol.
Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants. N Engl J Med 1985;313:474-479.
Guidelines in Emergency Medicine Network (GEMNet): guideline for the management of tricyclic antidepressant overdose.
The effect of toxic and therapeutic doses of tricyclic antidepressant drugs on intracardiac conduction.
As a tricyclic antidepressant, desipramine has sympathomimetic and anticholinergic effects, both of which are useful in suppressing vestibular symptoms.
While CNS stimulant drugs are prescribed to control the EDS associated with narcolepsy, tricyclic antidepressant drugs are prescribed to control cataplexy, sleep paralysis and hypnagogic hallucinations.
All of these findings suggest tricyclic antidepressant cardiotoxicity.
About a third of the subjects who had been prescribed a drug received a tricyclic antidepressant. The rest (13.5%) received drugs in other classes; only 0.2% of patients in the study were prescribed MAO inhibitors - too small a group to enter into the analysis.
According to research published in the December 2009 issue of Archives of Internal Medicine, postmenopausal women who take either a tricyclic antidepressant (TCA) or a selective serotonin-reuptake inhibitor (SSRI) face higher risks of all-cause mortality.