Chlorpromazine (Thorazine), clozapine (Clozaril), methotrimeprazine (Nozinan), olanzapine (Zyprexa), perphenazine (Trilafon), pimozide (Orap), quetiapine (Seroquel), thioridazine (Mellaril), and trifluoperazine
Antipsychotic Drugs: Clozapine, Olanzapine, Perphenazine, Quetiapine, Thioridazine, Trifluoperazine
, Loxapine, Methotrimeprazine, Molindone, Pimozide
In subsequent analyses, the authors found that among patients with affective disorders, only current use of medium--to high-potency FGAs (haloperidol, prochlorperazine, and trifluoperazine
) was associated with a significantly increased risk of seizures (adjusted odds ratio: 2.51, CI, 1.51 to 4.18) compared with non-users.
In previous works investigating the separation of the pharmaceutical-metal complexes [10, 11] and therefore, they proved that the ZIC-HILIC columns are able to separate des-ferrioxamine-metal and trifluoperazine
hydrochlo-ride-metal complexes by IC-ICP-AES.
Typically, high-potency first-generation antipsychotics such as trifluoperazine
and haloperidol are frequently associated with NMS as compared to the second-generation antipsychotics [1, 2].
([dagger]) Twelve patients were receiving olanzapine, 8 on quetiapine, 4 on risperidone, 2 on chlorpromazine, and 1 each on amisulpride, aripiprazole, and trifluoperazine
. ([double dagger]) Seven patients were receiving escitalopram, 5 each on sertraline and mirtazapine, 4 on bupropion, 2 on fluoxetine, and 1 each on venlafaxine and imipramine.
Therapy with certain psychoactive drugs has been described as successful, including trifluoperazine
hydrochloride, pimozide, olanzapine, lithium, doxepin, fluoxetine, and sertraline, as well as cognitive psychotherapy, hypnosis, and habit-reversal techniques (4, 8-13).
 Many antipsychotics (both typical and atypical) like chlorpromazine, fluphenazine, haloperidol, trifluoperazine
, amisulpride, olanzapine and risperidone have been implicated.
The distribution of typical and atypical antipsychotic exposures Antipsychotics n % Typical antipsychotics Thioridazine 4 6.1 Chlorpromazine 5 7.6 Mesoridazine 1 1.5 Trifluoperazine
3 4.5 Zuclopenthixol 1 1.5 Haloperidol 1 1.5 Total 15 22.7 Atypical antipsychotics Quetiapine 27 40.9 Risperidone 15 22.8 Olanzapine 8 12.1 Clozapine 1 1.5 Total 51 77.3 Total 66 100.0 Table 3.
Among the cases who used typical antipsychotic drugs, 39 (83%) were prescribed haloperidol, 5 (10.6%) were prescribed chlorpromazine while only 3 (6.4%) cases took trifluoperazine