trimethadione


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tri·meth·a·di·one

 (trī-mĕth′ə-dī′ōn′)
n.
A white crystalline substance, C6H9NO3, used as an anticonvulsant in the treatment of epilepsy.

trimethadione

(ˌtraɪmɛθəˈdaɪəʊn)
n
(Elements & Compounds) a crystalline compound with a bitter taste and camphor-like odour, used in the treatment of epilepsy. Formula: C6H9NO3
[from tri- + meth(yl) + di-1 + -one]
References in periodicals archive ?
Various antiepileptics have been implicated as causing factors of DILE, including phenytoin, trimethadione, primidone, ethosuximide, clobazam, valproic acid, and carbamazepine (CBZ) (1, 4).
Trimethadione, the first treatment specifically for absence seizures was licensed in the1940s, following laboratory evaluation with the pentylenetetrazole (PTZ) animal seizure model by Richards and Everett, in 1944, and clinical evaluation by Lennox in 1945.
Yasuhara, "Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione Ndemethylation in human microsomes," Journal of Clinical Pharmacy and Therapeutics, vol.
Studies have shown propylene glycol can influence seizures in animal models of epilepsy and warn against using propylene glycol as the solvent to dissolve epileptic drugs such as carbamazepine, trimethadione, and benzodiazepines [2, 3,11,13].
TABLE 1 Drugs that are potential acne triggers Common drugs/drug classes Anabolic steroids (eg, danazol and testosterone) Bromides and iodides Corticosteroids (eg, prednisone) Corticotropin Isoniazid and ethionamide Lithium and barbiturates Phenytoin and trimethadione Less common drugs Azathioprine Cyclosporine Disulfiram Phenobarbital Quinidine Adapted from: Sterry W, et el.