Leaves contain chlorogenic acid, and datugenin, cuscohygrine, scopolamine and tropine
, cumarins and tannins.
The animal was shifted to squeeze cage for anaesthesia and was premedicated with Atropine sulphate (a) (Tropine
) @0.04mg/kg b.
This corresponds to calculated p[K.sub.b] 7.0 and 8.6 for these bases; thus, granatanone is a slightly weaker base than tropinone (both amino ketones are weaker than closely related amino alcohol, tropine
(estimated p[K.sub.b] ca.
Other details of the multi-location multi-phase FDA compliant Tropine
3 clinic trials are likely to be finalised within the next few weeks.
For premedication, Atropine sulphate (Tropine
(a)) @ 0.04 mg/kg b.
Algorithm: "PEAT" P acer--consider a pacer first E pinephrine A tropine
The first successful investigation of Kirkwood's quest for the de novo origin of heterocyclic systems of alkaloids from carbon-14 labelled acyclic precursors was an experiment to test whether an N[C.sub.4] chain derived from the amino acid ornithine served as the precursor of the [C.sub.4]N ring system of the alkaloid tropine
. This work was designed and carried out by Edward Leete and Ian Spenser, post-doctoral fellows in Leo Marion's laboratory.