Leaves contain chlorogenic acid, and datugenin, cuscohygrine, scopolamine and tropine
, cumarins and tannins.
Biosynthesis of tropine
moiety of hyoscyamine from D-N-methylornithine.
Then, compounds with higher affinity for muscarinic receptors were synthesized by introducing a tropine
or quinuclidinyl group instead of a piperazine group (Nos.
Pristine Solutions holds the intellectual property and global marketing rights to Tropine
3, a patent pending novel indication of an existing FDA approved drug for the non- hormonal treatment of hot flashes in pre-menopausal, peri- menopausal and post-menopausal women, through Eaton Scientific Systems.
In the southern US, anticholinergic plant poisoning is frequently caused by several species of three closely related plant genera (Brugmasia, Datura, and Solandra) from the nightshade or Solanaceae family that contain combinations of tropine
alkaloids, including atropine, hyoscyamine, and scopolamine (Figure 2).