tropomyosin


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tro·po·my·o·sin

 (trō′pə-mī′ə-sĭn, trŏp′ə-)
n.
A protein that binds to and stabilizes actin filaments in cells. In skeletal and cardiac muscle cells, tropomysin is released after interacting with troponin and calcium, facilitating the binding of actin to myosin that causes muscle contraction.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

tropomyosin

(ˌtrɒpəʊˈmaɪəsɪn)
n
a protein in muscle tissue that works with troponin to control the process by which actin and myosin interact to produce muscle contraction
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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References in periodicals archive ?
A, Representative image of primary cultured of cardiomyocytes in immunocyto-chemistry for sarcomeric tropomyosin and for vimentin by a confocal microscope.
The troponin complex is composed of three subunits: 1) troponin C (TnC), 18 kDa, which has binding sites for calcium; 2) troponin I (TnI), 20-24 kDa, coupled with actin, which interferes with the binding of myosin to actin at low calcium concentrations (inhibitory effect); and 3) troponin T (TnT), 31-36 kDa, that binds the troponin complex with tropomyosin. One troponin complex is present for every seven actins molecules along thin filaments (Gordon et al.; Moore et al., 2016; Lin et al, 2017).
The experiments indicated that when dectin-1 recognizes tropomyosin in house dust mites, shrimp or other common allergy-triggering species it suppresses airway cells' production of an immune molecule, IL-33, which otherwise would promote an allergic response by immune cells.
Chronic pain sufferers often have higher nerve growth factor levels, which interact with tropomyosin receptor kinase A to moderate pain.
In the cell, the S100A4 protein interacts with the cytoskeletal proteins like nonmuscle myosin heavy chain (NMMHC) IIA, tropomyosin, actin, and filaments.
Lu et al., "Fisetin provides antidepressant effects by activating the tropomyosin receptor kinase B signal pathway in mice," Journal of Neurochemistry, vol.
[H.sub.2]S has a role in tropomyosin receptor kinase B (TrKB) and glutamate as well as mechanistic targets of rapamycin (mTOR) signaling pathways, and it activates the TrKB-mTOR signaling pathway as well as synaptic protein in MDD.
For instance, shrimp has high-level tropomyosin, which is the factor for causing food allergies [7].
In meat samples, the main protein bands identified in the range of molecular weights from 250 to 10kDa were myosin heavy chain (MHC), [alpha]-actinin ([alpha]-act), desmin, actin (ACT), troponin T (TnT), tropomyosin (TPM), myosin light chains 1 (MLC1), troponin C (TnC), and myosin light chains 2 (MLC2).
Especially, they indicated the dramatic increase in 2 tropomyosin isoform expressions in hypoxic condition in a HIF-1[alpha]-dependent manner.
Nemaline bodies, or rods, contain Z-line material and thin filament material (alpha-actinin, actin and tropomyosin with or without desmin at the periphery).
Molecular studies could detect genetic aberrations including a clonal origin, chromosomal abnormalities involving 2p23, fusion of the ALK gene with tropomyosin 3 (TPM3-ALK) or tropomyosin 4 (TPM4-ALK), translocations of ROS1 gene, RET mutations, or alterations using comparative genomic analysis CGH [2, 13-16].