Cardiac troponin [cardiac troponin I
(cTnI) and cTnT] has become globally recognized as the standard biomarker for the diagnosis of acute myocardial infarction (AMI).
27 September 2013 - Beckman Coulter Inc, part of US Danaher Corporation (NYSE:DHR), said Thursday it had received 510(k) approval from the US FDA for its Access AccuTnI+3 troponin I
assay for use on the UniCel DxI series of immunoassay systems.
In 14 patients (29%), myocardial damage was classified as significant based upon an admission cardiac troponin I
greater than 0.6 ng/mL.
Direct comparison of high-sensitivity-cardiac troponin I
20 June 2013 - Beckman Coulter Inc, part of Danaher Corporation (NYSE:DHR), said on Wednesday it had obtained US FDA 510(k) clearance for its new Access AccuTnI+3 troponin I
assay for use on its Access 2 immunoassay system.
In a prospective study of 118 consecutive cases of acute pericarditis treated over 2 years, the researchers assessed cardiac troponin I
levels obtained from venous blood samples within 24 hours of symptom onset.
using pooled data from 5 cohort studies recently reported lower sensitivities for both high-sensitivity troponin T at 94.8% (95% CI 89.6%-97.9%) and high-sensitivity troponin I
at 93.2% (95% CI 87.5%-96.8%) measured at presentation and at 3 h, raising further questions about the safety of this approach in clinical practice (21).
These findings suggest that high serum levels of troponin I
may be a good way to identify patients who have a pulmonary embolism (PE) and could benefit from aggressive throm-bolysis, Dr.
Neumann, M.D., from the University Heart Center Hamburg in Germany, and colleagues determined the concentrations of high-sensitivity troponin I
or high-sensitivity troponin T in 15 international cohorts of patients with symptoms suggestive of myocardial infarction; troponin was measured at presentation to the emergency department and after early or late serial sampling.
A total of 1,599 patients in the SUMMIT trial had a baseline cardiac troponin I
assessment, and 1,258 had a follow-up assessment at 3 months following randomization.
When a patient experiences chest pains, a blood test can determine if troponin is
Cardiac troponin I
(cTnl) and T (cTnT) have a high sequence homology across phyla and are sensitive and specific markers of myocardial damage; Homology between canine and feline genes and humans was 95 and 96 percent, respectively (Burgener et al., 2006; Wells and Sleeper, 2008).