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NF kappa B inhibitors and anti trypanosomal metabolites from endophytic fungus Penicillium sp.
Furthermore, we conclude that the described sensitivity of the trypanosomal in vitro RNA editing system [24] cannot be attributed to the structure of the preedited substrate mRNAs, which suggests that the catalytic machinery that is the editosome might be sensitive to volume exclusion conditions.
Comparative Evaluation of parasitological, serological and DNA amplification methods for diagnosis of natural trypanosomal infection in equines.
Leucopenia in animal trypanosomosis has been attributed to factors such as trypanosomal antigen coating of leucocytes and depression of leucocyte production [7].
synthesized compounds based on 5-benzyl-2,4-diaminopyrimidines and evaluated the compounds as inhibitors of leishmanial and trypanosomal dihydrofolate reductase.
Of the Leishmanial and trypanosomal Hsp70s and Hsp40s, a number of important and well-known studies have been performed on T.
The crystal structure of PfTPI has been solved based on the structure of trypanosomal triosephosphate isomerase.
Reverse transcriptase activity of HERV origin can integrate archaeal genomes into the human genome as has been demonstrated with regard to trypanosomal genomes in Chagas disease.
Hansell et al., "Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain," Journal of Medicinal Chemistry, vol.
Inhibitors of Cathepsin B need to be highly specific against the trypanosomal variant because it resembles the human form.
That is true also for the trypanosomal amastigotes of Chagas disease, which are identical in appearance except that unlike Leishmania they have no predilection for histiocytes.