tubocurarine


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tu·bo·cu·ra·rine

 (to͞o′bō-ko͝o-rä′rĭn, -rēn′, -kyo͝o-, tyo͞o′-)
n.
1. An alkaloid that is an active component of curare obtained from the plant Chondrodendron tomentosum.
2. The hydrated chloride form of this alkaloid, C38H44Cl2N2O6, used as a drug to relax skeletal muscles during anesthesia.

[Latin tubus, tube (from the practice of shipping it in bamboo tubes) + curarine (curare + -ine).]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

tubocurarine

(ˌtjuːbəʊkjʊˈrɑːriːn)
n
a toxic alkaloid obtained from the stem of a S American vine. Formula: C37H42Cl2N2O6
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

tu•bo•cu•ra•rine

(ˌtu boʊ kyʊˈrɑr in, -ɪn, ˌtyu-)

n.
the principal active alkaloid of curare, C38H44Cl2N2O, used as a muscle relaxant, esp. as an adjunct to anesthesia.
[1895–1900; < German Tubocurarin=Tubocurar(e) (see tube, -o-, curare) + -in -in1]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tubocurarine - a toxic alkaloid found in certain tropical South American trees that is a powerful relaxant for striated muscles; "curare acts by blocking cholinergic transmission at the myoneural junction"
alkaloid - natural bases containing nitrogen found in plants
neuromuscular blocking agent - a substance that interferes with the neural transmission between motor neurons and skeletal muscles
phytotoxin, plant toxin - any substance produced by plants that is similar in its properties to extracellular bacterial toxin
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
The protein nanoparticle bound drugs include loperamide, tubocurarine, and doxorubicin.
Among the established agents, tubocurarine, gallamine, and pancuronium exert significant cardiovascular effects; atracurium and mivacurium produce minor changes in cardiovascular variables whereas vecuronium and rocuronium are associated with a high degree of cardiostability.
Several significant modern drugs such as digitoxin reserpine tubocurarine ephedrine ergometrine atropine vinblastine and aspirin had their origins in traditional folk medicines [2 9].
Modern drugs like aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine, and tubocurarine are examples, which were originally discovered through observations of traditional cure methods of indigenous peoples [19].
in 2007 [20] showed in human leukocytes that antagonists of the nicotinic and muscarinic receptors (tubocurarine and atropine, resp.) could significantly decrease the phagocytic functions of granulocytes but did not change the migration of these cells, whereas in Jurkat cells (the human helper T-lymphocyte leukemic line) exposure to oxotremorine-M (Oxo-M), a cholinergic agonist, could significantly increase the synthesis of IL-2, which could be related to the transcriptional factor activator protein-1 (AP-1) and mitogen-activated protein kinases (MAPK) [21].
Modern drugs like aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine are examples, which were originally discovered through observations of traditional cure methods of indigenous peoples.
Neuromuscular transmission which was suppressed by tubocurarine in the in vitro preparation could be briefly restored by application to the nerve of two or more very closely spaced stimuli; this occurred because of summation of endplate potentials.
Some of the useful plant drugs include vinblastine, vincristine, Taxol, Podophyllotoxin, camptothecin, digitoxigenin, gitoxigenin, digoxigenin, tubocurarine, morphine, codeine, aspirin, atropine, Pilocarpine, capsicum, Ellison, curcumin, artemesinin and ephedrine among others.
Rich., the skeletal muscle relaxant tubocurarine from Strychnos toxifera Bentham, and the antimicrobial compounds berberine and sanguinarine from divergent plant species including Berberis spp.
Nicotinic receptor mediated diaphragm contractions were fully inhibited by catharanthine ([IC.sub.50] = 59.6 [micro]M) and ajmalicine ([IC.sub.50] = 72.3 [micro]M), in a reversible but non-competitive manner, unlike the more potent nicotinic antagonist tubocurarine ([IC.sub.50] = 0.35 [micro]M) whose competitive blockade was overcome by a physostigmine-induced increase in acetylcholine.
Chondodendron tomentosum is a native of South America and produces the alkaloid tubocurarine, the principal ingredient in curare.