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Related to tubulin: alpha tubulin


 (to͞o′byə-lĭn, tyo͞o′-)
A globular protein that is the basic structural constituent of microtubules.


a protein that forms the basis of microtubules


(ˈtu byə lɪn, ˈtyu-)

a globular protein that is a structural subunit of the microtubule.
References in periodicals archive ?
While the cytotoxins used in the majority of advanced programs in the field prevent tubulin polymerization during cell division, Synthon's differentiating linker-drug technology - applying valine-citrulline-seco-DUocarmycin- hydroxyBenzamide-Azaindole (vc-seco-DUBA) - is based on synthetic duocarmycin analogs, which bind to the minor groove of DNA and subsequently cause irreversible alkylation of DNA.
KX2-391, also known as KX-01, is a novel dual Src kinase and tubulin polymerization inhibitor that Athenex is developing into a topical formulation for the treatment of actinic keratosis.
In fact, the analysis of the b- tubulin gene variation seems to confirm that the T.
It functions by binding to tubulin at a site not targeted by any approved microtubule-targeting agent (MTA).
Their topics include post-translational modifications of tubulin and cilia, the central apparatus of cilia and eukaryotic flagella, transition zone migration: a mechanism for cytoplasmic ciliogenesis and postaxonemal centriole elongation, primary cilia and mammalian hedgehog signaling, G-protein-coupled receptor signaling in cilia, ciliary mechanisms of cyst formation in polycystic kidney disease, sperm sensory signaling, cilia and ciliopathies in congenital heart disease, photoreceptor cilia and retinal ciliopathies, and the evolution of cilia.
The use of tubulin-targeting agents is limited by the development of resistance to anticancer drugs, which is induced by tubulin isotype mutation and the alteration of microtubule dynamics (Cheung et al.
It possesses cytotoxic anti-tubulin activity by binding to the colchicine site of tubulin causing microtubule depolymerization.
accumulation of tubulin and microtubular cytoskeleton are induced during seed imbibition and that cell division may occur as a post-germination phenomenon with radicle protrusion occurring by cell elongation, or as a pre-germination phenomena (DE CASTRO et al.
Furthermore the current studies show that VTN can promote cell adhesion and contribute to the maintenance of Tubulin structures.
When mercury is introduced to the neurons even in small doses, within minutes the tubulin stops growing and starts to degenerate.
It binds to AY- tubulin and thus preventing polymerization of tubulin dimers to microtubules (Lacey, 1988).