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Related to tubulin: alpha tubulin


 (to͞o′byə-lĭn, tyo͞o′-)
A globular protein that is the basic structural constituent of microtubules.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


a protein that forms the basis of microtubules
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈtu byə lɪn, ˈtyu-)

a globular protein that is a structural subunit of the microtubule.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
Treatment with KX2-391 ointment 1%, a dual Src kinase and tubulin polymerization inhibitor, met the primary endpoint of 100% clearance of AK lesions on the face and scalp on day 57 in 44% and 54% of those treated in the two studies, compared with 5% and 13%, respectively, of those in the vehicle groups.
In addition, HDAC6 inhibition can enhance acetylation of cytoplasmic tubulin and lose the capability to clear unfolded or misfolded proteins, thereby promoting cell apoptosis.
(6-8) All of these processes are mediated by GTPase proteins, including elongation factors, (9) tubulin, (10) and dynamin family members.
Literature reviews revealed pathogenic variants in the TUBBI (Tubulin Beta 1 Class VI), TUBBI (Tubulin Beta 2 Class II), TUBB3 (Tubulin Beta 3 Class III) (3), TUKLS (Tukel syndrome) (6), KIF21A (Kinesin Family Member 21 A) (8), COL2A1 (Collagen Type XXV Alpha 1 Chain) (7) and PHOX2A (Paired Like Homeobox 2a) (2) genes in different types of CFEOM.
During the training, Dana learned new techniques such as molecular modelling and docking, enzyme kinetics and tubulin assay, animals handling and in vivo testing, and performed experiments related to discovering novel therapies for the treatment of breast cancer.
Several reports suggest the occurrence of an electrical storm among 10% to 20% of implantable cardioverter-defibrillator (ICD ) recipients.1-4 Microtubules are the key components of the cytoskeleton of eukaryotic cells and have an important role as railways in various cellular functions such as intracellular migration and vesicle transport, cell shape maintenance, polarity, cell signaling, and mitosis.5 In addition, colchicine binding to beta-tubulin results in curved tubulin dimer and prevents it from adopting a straight structure.
While the cytotoxins used in the majority of advanced programs in the field prevent tubulin polymerization during cell division, Synthon's differentiating linker-drug technology - applying valine-citrulline-seco-DUocarmycin- hydroxyBenzamide-Azaindole (vc-seco-DUBA) - is based on synthetic duocarmycin analogs, which bind to the minor groove of DNA and subsequently cause irreversible alkylation of DNA.
Microtubules were labeled with mouse monoclonal anti-[alpha] tubulin (Sigma-T9026) diluted to 0.5 [micro]L/mL by 1% BSA/PBS (containing 0.1% TritonX) by incubating for 24 h at room temperature.
The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles.
In fact, the analysis of the b- tubulin gene variation seems to confirm that the T.
For the samples fixed with Clarke's reagent, clear labeling of tubulin is noticed (Fig.
Cells were then incubated with the following primary antibodies at 4[degrees]C overnight: rabbit anti-Ki67 (1:1000, Abcam), mouse anti-nestin (1:300, Abcam), goat anti-CXCR4 (1:300, Abcam), rabbit anti-[beta]III tubulin (1:300, Epitomics), rabbit anti-GFAP (1:7000, Abcam), rabbit anti-SOX2 (1: 300, Abcam), and rabbit anti-CNPase (1: 1000.