5 In addition, colchicine binding to beta-tubulin
results in curved tubulin
dimer and prevents it from adopting a straight structure.
While the cytotoxins used in the majority of advanced programs in the field prevent tubulin
polymerization during cell division, Synthon's differentiating linker-drug technology - applying valine-citrulline-seco-DUocarmycin- hydroxyBenzamide-Azaindole (vc-seco-DUBA) - is based on synthetic duocarmycin analogs, which bind to the minor groove of DNA and subsequently cause irreversible alkylation of DNA.
KX2-391, also known as KX-01, is a novel dual Src kinase and tubulin
polymerization inhibitor that Athenex is developing into a topical formulation for the treatment of actinic keratosis.
In fact, the analysis of the b- tubulin
gene variation seems to confirm that the T.
It functions by binding to tubulin
at a site not targeted by any approved microtubule-targeting agent (MTA).
Their topics include post-translational modifications of tubulin
and cilia, the central apparatus of cilia and eukaryotic flagella, transition zone migration: a mechanism for cytoplasmic ciliogenesis and postaxonemal centriole elongation, primary cilia and mammalian hedgehog signaling, G-protein-coupled receptor signaling in cilia, ciliary mechanisms of cyst formation in polycystic kidney disease, sperm sensory signaling, cilia and ciliopathies in congenital heart disease, photoreceptor cilia and retinal ciliopathies, and the evolution of cilia.
The use of tubulin
-targeting agents is limited by the development of resistance to anticancer drugs, which is induced by tubulin
isotype mutation and the alteration of microtubule dynamics (Cheung et al.
It possesses cytotoxic anti-tubulin
activity by binding to the colchicine site of tubulin
causing microtubule depolymerization.
accumulation of tubulin
and microtubular cytoskeleton are induced during seed imbibition and that cell division may occur as a post-germination phenomenon with radicle protrusion occurring by cell elongation, or as a pre-germination phenomena (DE CASTRO et al.
Furthermore the current studies show that VTN can promote cell adhesion and contribute to the maintenance of Tubulin
When mercury is introduced to the neurons even in small doses, within minutes the tubulin
stops growing and starts to degenerate.
It binds to AY- tubulin
and thus preventing polymerization of tubulin
dimers to microtubules (Lacey, 1988).