tumor necrosis factor


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Related to tumor necrosis factor: Interleukin 1

tumor necrosis factor

n.
Abbr. TNF Any of a family of small transmembrane proteins that can be released as soluble cytokines, are produced especially by monocytes and macrophages, and perform a variety of functions including activating inflammatory processes and causing cell death.

tu′mor necro`sis fac`tor


n.
a protein, produced in humans and other animals, that is destructive to cells showing abnormally rapid growth. Abbr.: TNF
[1985–90]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tumor necrosis factor - a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
cytokine - any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system
References in periodicals archive ?
s) tumor necrosis factor alfa inhibitors, Designated according to the indications of the list of centralized medicinal products and medical aid measures.
The report provides comprehensive information on the Tumor Necrosis Factor Receptor Superfamily Member 5 (B-Cell Surface Antigen CD40 or CD40L Receptor or CD40), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
The association between type 2 diabetes mellitus and psoriasis also might be owing to increased tumor necrosis factor production from psoriatic inflammation and low-grade obesity inflammation, because it contributes to insulin resistance," they wrote.
To look specifically at the impact on bone loss, the researchers crossed mice bred to overexpress tumor necrosis factor alpha throughout the body with mice that overexpressed GILZ in just their mesenchymal stem cells.
The tumor necrosis factor alpha and its soluble receptor profile in term and preterm parturition.
Much more work needs to be done before scientists understand the role of tumor necrosis factor in AD and determine whether anti-TNF-type drugs can safely and effectively treat the disorder.
Tumor necrosis factor production by monocytes infiltrating atherosclerotic lesions is a key factor in the genesis and progression of vascular damage, and oxidative stress of the vascular wall sustained by circulating activated PMNs is an early step in the cascade leading to cardiovascular pathology in otherwise asymptomatic individuals.
Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients.
While an anti-tumor necrosis factor antibody, infliximab, had been effective for a substantial fraction of patients with Crohn's disease, another tumor necrosis factor inhibitor, etanercept, was of no benefit to patients in a placebo-controlled study with 43 patients.
24] They treated an elderly woman with disease of the lower extremity with tumor necrosis factor and melphalan and reported no evidence of recurrent disease at 2 years of followup.
With partial support from the remainder of hr Society postdoctoral fellowship, she began to study a particular kind of cytokine called tumor necrosis factor (TNF), which is an agent that affects a tumor by "chewing" up the blood vessels that nourish it, leading to tumor death.

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