tumor necrosis factor

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Related to tumor necrosis factor: Interleukin 1

tumor necrosis factor

Abbr. TNF Any of a family of small transmembrane proteins that can be released as soluble cytokines, are produced especially by monocytes and macrophages, and perform a variety of functions including activating inflammatory processes and causing cell death.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

tu′mor necro`sis fac`tor

a protein, produced in humans and other animals, that is destructive to cells showing abnormally rapid growth. Abbr.: TNF
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tumor necrosis factor - a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
cytokine - any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system
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References in periodicals archive ?
The silent progression of metastatic malignancy during the treatment with soluble tumor necrosis factor receptor.
Jack Lichtenstein noted that he had observed that several of his patients receiving tumor necrosis factor (TNF) inhibitors developed severe methicillin-resistant S.
Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis.
Tumor necrosis factor production by monocytes infiltrating atherosclerotic lesions is a key factor in the genesis and progression of vascular damage, and oxidative stress of the vascular wall sustained by circulating activated PMNs is an early step in the cascade leading to cardiovascular pathology in otherwise asymptomatic individuals.
Effects of a polymorphism in the human tumor necrosis factor [alpha] promoter on transcriptional activation.
Cerami, "Tumor necrosis factor: a pleiotropic cytokine and therapeutic target," Annual Review of Medicine, vol.
The supplemental approval comes a year after the FDA approved tocilizumab, an interleukin-6 receptor inhibitor for the treatment of adults with moderately to severely active RA who have had an inadequate response to one or more tumor necrosis factor antagonist therapies.
The medical records of more than 5,000 patients were evaluated over a five-year period to assess the risk of bacterial infection among those who use drugs that inhibit tumor necrosis factor (TNF).
enumerate the multiple, distinct receptor homologs and binding proteins encoded by poxviruses that target tumor necrosis factor. L.K.
(Rockville, MD) and University of Michigan (Ann Arbor, MI) have patented Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor receptor family.
As the body lurches into a self-defense mode, it mass-produces inflammatory proteins, such as tumor necrosis factor alpha (TNF-alpha) and high-mobility group box 1 (HMGB1).

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