tumor suppressor gene


Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.
Related to tumor suppressor gene: oncogene, Proto oncogene

tumor suppressor gene

n.
Any of various genes that normally suppress cellular proliferation and that, when mutated, are associated with the development of certain cancers, including many familial cancers. Also called antioncogene.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tumor suppressor gene - a suppressor gene that blocks unscheduled cell division
suppresser gene, suppressor gene, suppresser, suppressor - a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
[USA], Sep 22 ( ANI ): Turns out, mutations in the tumor suppressor gene SPOP contribute to cancer by disrupting a process called liquid-liquid phase separation.
Mitochondrial tumor suppressor 1 (MTUS1) gene is known as a candidate tumor suppressor gene encoding a family of angiotensin II receptor-interacting proteins (ATIP) [12].
Hence, MBD1 might be a tumor suppressor gene in advanced CRC.
Recessive changes- Those occur in growth-inhibitory pathway genes or commonly in tumor suppressor genes causing loss of function.
CU-Boulder Professor Min Han said the research team was interested in how a common tumor suppressor gene known as Retinoblastoma 1, or Rb, behaved under conditions of starvation.
Mutations of tumor suppressor gene P53 (TP53) in tumor tissue and cellular urine sediments in urinary bladder cancer.
In recent years he has become more interested in targeting the oncogene P53 tumor suppressor gene, developed a therapy (PSJ53 therapy), and had some important success.
When the researchers measured cells in breast milk from 13 women who turned out to have cancer, these cells had substantially more methylation in a tumor suppressor gene called RASSF1 than did cells from the noncancerous breast.
The tumor suppressor gene p53 appears to play a key role in keeping cells healthy and preventing them from starting the abnormal growth that is a hallmark of cancer.
This region contains the Lung Cancer Tumor Suppressor Gene Region 1 (LCTSGR1), where genes as RASSF1A, HYAL2/LUCA, FUS1/TUSC2,101F6/CYB561D2, and CPR2L/CPRL2/ TUSC4, are located.
Identification of the von Hippel-Lindau disease tumor suppressor gene. Science.