MiR-142 functions as a tumor suppressor with diverse targets in many cancers, as it repressed the tumorigenicity
of human breast cancer stem cells via activating the WNT signaling pathway (24).
and genetic profling of circulating tumor cells in smallcell lung cancer.
For example, during the reprogramming process, some tumor suppressor genes may be deleted, and this may affect the iPSCs' abilities to differentiate, proliferate and develop, and may cause tumorigenicity
.  Thus, the ethical and moral aspect of these treatments is still being discussed, and it is generally accepted that the requirements for proof of principle and safety should be higher, particularly if the cells have been manipulated extensively in vitro or have been derived from pluripotent stem cells.
assay of the differentiated cells cultured in the chips in nude mice
let-7 regulates self-renewal and tumorigenicity
of breast cancer cells.
They were then tested for the ADMET properties, mutagenicity and tumorigenicity
using the Swiss ADME tool (Table 4).
A recent study using PPAR[gamma] siRNA showed that PPAR[gamma] suppression inhibits cell proliferation, colony formation, and tumorigenicity
in vivo .
H19 overexpression enhances invasion, angiogenesis, stemness, and tumorigenicity
of GBM cells, whereas H19 depletion has opposite effects [90, 91].
Evaluation ofAF-MSC Tumorigenicity
. Female Balb/c nude mice that were 4 weeks old were randomly assigned to experimental groups.
It was reported that ApoA-I established antitumor properties by interacting with C1QBP in colon cancer, and ApoA-I could also inhibit colitis-propelled carcinogenesis and modulate tumorigenicity
and immunogenicity [36-39].
Analysis of Water Samples in Cell Transformation Assay.
The two kinds of cells are tumorigenic, especially NG10815 cells have very strong tumorigenicity
, invasiveness, and migration capability [28, 29].