tumour necrosis factor

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Related to tumour necrosis factor: Cytokines, Interleukins
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Noun1.tumour necrosis factor - a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
cytokine - any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system
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References in periodicals archive ?
Efficacy of tumour necrosis factor blockers in reducing uveitis flares in patients with spondylarthropathy: a retrospective study.
Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.
It was reported yesterday that the collaboration is aimed at Inhibrx's novel glucocorticoid-induced tumour necrosis factor receptor antibody programme, which is presently at lead selection stage.
Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product.
Wilcock, "Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease," Experimental Gerontology, vol.
Cazlaris et al., "Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis," EMBO Journal, vol.
One such protein is a tumour necrosis factor, which is involved in cell death and can trigger the production of another problematic protein, called MAP4K4, which blocks the formation of insulin when cells are under adverse conditions.
Tumour necrosis factor (TNF) is prominent among them.
In 2008, Nice said patients would not able able to try a second anti-TNF (tumour necrosis factor alpha inhibitor) if their first attempt at anti-TNF therapy failed.

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