- Auth = authors; n = number; pat = patients; y = years; OW = oval window; PLF = perilymphatic fistula; RW = round window; SHL = sensorineural hearing loss; tinn = tinnitus; audiom = audiometric; VNG = videonystagmography; reconst = reconstruction; M = male; F = female; pos = positive; RX = radiography; neg = negative; Ny = nystgamus; CT = computed tomography; vestib = vestibular; temp = temporalis; expl tymp
= exploratory tympanotomy; doubt = doubtful; pericondr = pericondrium Table 2.
After examination of the outer and middle ear, tympanometry (GSI 38 Auto Tymp
; Grason-Stadler Inc., Milford, NH, USA) was employed as a means of screening children for middle ear function.
Quantitative gene expression assays for excision repair (ERCC1), thymidine phosphorylase (TYMP
), stathmin (STMN1), ribonucleotide reductase (RRM1) and other genes provide valuable information to help predict chemotherapy responses.
Within the included operations, 5 patients had undergone bilateral surgery, 4 had a second look combined approach tymp
anoplasty, and further 4 patients had revision surgery or a conversion procedure (e.g., canal wall up converted to canal wall down).
Thymidine phosphorylase (TYMP
) is an enzyme involved in pyrimidine metabolism and also known to be a platelet-derived endothelial cell growth factor (PD-ECGF).
The Grason-Stadler Tymp
Star middle ear analyzer (Grason-Stadler; Eden Prairie, Minnesota) and MAICO EasyTymp (MAICO Diagnostic, GmbH; Eden Prairie, Minnesota) used in the study were calibrated annually.
MDDSs cause a reduction in cellular mtDNA content (2).At the present time, mutations in at least 9 genes [POLG,  polymerase (DNA directed), gamma; DGUOK, deoxyguanosine kinase; TK2, thymidine kinase, mitochondrial; TYMP
, thymidine phosphorylase; MPV17, MpV17 mitochondrial inner membrane protein; SUCLA2, succinate-CoA ligase, ADP-forming, beta subunit; SUCLG1, succinate-CoA ligase, alpha sub unit; RRM2B, ribonucleotide reductase M2 B (TP53 inducible); C10orf2, chromosome 10 open reading frame 2 (also known as TWINKLE)] have been found to cause mtDNA depletion (3-17).
(yrs) Gender Address group (yrs) P1 23 F MD Sotho 5 P2 27 F MD Sotho 4 P3 23 F MD Sotho 1 P4 9 F MD Sotho 13 P5 20 M MD Sotho 4 P6 26 F MD Zulu 4 P7 49 F MD Sotho 6 P8 30 F MD Sotho 10 P9 33 F MD Sotho 3 P10 18 F MD Sotho 1 P11 24 F MD Sotho 14 P12 65 M MD Sotho 5 P13 30 F MD Sotho 5 P14 57 F MD Sotho 3 P15 55 M MD Sotho 6 P16 32 M CT Xhosa 4 P17 54 M CT Xhosa 10 P18 31 F CT Xhosa 4 P19 36 M CT Xhosa 3 P20 63 F CT Xhosa 10 P21 61 M CT Xhosa 2 P22 56 F BF Sotho 2 P23 37 F BF Sotho 9 P24 53 M BF Sotho 14 P25 50 F BF Sotho 4 P26 32 F BF Sotho 1 P27 41 F BF Sotho 5 P28 29 F BF Sotho 2 P29 50 F BF Sotho 5 P30 52 M BF Sotho 7 P31 48 F BF Sotho 10 Tymp
. ABG No.
In this study--a follow-up to an earlier study (N Engl J Med 2005; 353:576; discussed in the POEM "Early tymp
tubes do not improve outcomes after 3+ years," J Fam Pract 2005; 54:929)--429 children between the ages of 2 months and 3 years with middle-ear effusion for at least 90 days (bilateral) or 135 days (unilateral) were randomized to receive either prompt or delayed tympanostomy tube insertion.
Physicians prescribed antibiotics to 29% of 341 children in the "Tymp
Aware" group, and 27% of children in the "Tymp