In the West, duodenal perforation is more common and generally confined in the elderly population who are on ulcerogenic
drugs, 1 while among the Orientals in Japan, gastric perforations are more due to increased incidence of gastric malignancy (6).
The risk of gastrointestinal hemorrhage may be increased when administering deferasirox in combination with drugs that have ulcerogenic
or hemorrhagic potential, such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, oral bisphosphonates, or anticoagulants.
and healing impairing actions of monochloramine in rat stomachs: effects of zinc L-carnosine, polaprezinc.
(32) Meloxicam is a selective COX-2 inhibitor with low molecular mass and high tissue tolerability, (33) and as a result meloxicam has a high intrinsic activity combined with a low ulcerogenic
potential it has a therapeutic index lower than piroxicam, diclofenac and indomethacin.
There are some conflicting reports showing its ulcerogenic
Previous studies have demonstrated that experimental gastric ulcers have many histological and ultrastructural abnormalities, including a reduced height, marked dilation of gastric glands, and increased connective tissue, that may interfere with the mucosal defense system and cause ulcer recurrence with some ulcerogenic
factors [22, 23].
The prevalence of taking ulcerogenic
drugs (NSAID, aspirin, clopidogrel, ticlopidine, and steroids) was 4.9% in patients with LC.
Sarkate, "Anti-Inflammatory, Analgesic, Ulcerogenic
Activities of Some New Non-Acidic Diclofenac and 1, 3, 4- Oxadiazole Derivatives in Animal Models," Pharmacologyonline, vol.
Mean age in Original Boey study was 51 years and omitted advanced age, elderly women population with ulcerogenic
medications like Non-steroidal Anti-inflammatory Drugs (NSAIDS), sample size from developing countries, prognostic factors like tachycardia (Heart Rate >100 beats/minute), acute renal failure, delay from time of perforation to hospital admission; thus causing extremely variable results in successive studies in literature [5,6,7]
Ahmad, "Diclofenac sodium loaded-cellulose acetate butyrate: effect of processing variables on microparticles properties, drug release kinetics and ulcerogenic
activity," Journal of Microencapsulation, vol.
It is free of adverse systemic effects and is not ulcerogenic
. Gingivitis involves inflammation of gums which leads to destruction and breakdown of periodontal structures resulting in increased pocket depth, clinical attachment loss, and destruction of alveolar bone.
Flavonoid-based biocompounds were also reported to promote formation of the gastric mucosa, inhibit pepsinogen production, decrease acid mucosal secretion, and reduce ulcerogenic